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Update on antiphospholipid antibody syndrome.
Michelle Remião Ugolini Lopes1, Adriana Danowski2, Andreas Funke3
1MD, Assistant Physician, Antiphospholipid Syndrome and Systemic Lupus Erythematosus Outpatient Clinic, Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
Antiphospholipid syndrome (APS) is an autoimmune disorder causing blood clots and pregnancy issues due to antiphospholipid antibodies (aPL). Current treatments focus on anticoagulation and antiplatelet therapies, despite its autoimmune origins.
Area of Science:
- Immunology
- Rheumatology
- Hematology
Background:
- Antiphospholipid syndrome (APS) is an autoimmune condition.
- It is defined by antiphospholipid antibodies (aPL).
- APS is linked to thrombosis and pregnancy complications.
Purpose of the Study:
- To review the clinical features of APS.
- To discuss the challenges in managing APS.
- To highlight current treatment strategies.
Main Methods:
- Literature review of APS.
- Analysis of clinical manifestations.
- Evaluation of treatment protocols.
Main Results:
- APS involves thrombotic events in various vessels.
- Non-criteria manifestations like thrombocytopenia and nephropathy add to morbidity.
- APS can occur independently or with systemic lupus erythematosus (SLE).
Conclusions:
- APS management remains challenging.
- Current treatments rely on anticoagulation and antiplatelet therapy.
- Further research into APS pathogenesis and targeted therapies is needed.
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