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Updated: Feb 14, 2026

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
Published on: March 18, 2022
Relationship between subchondral bone microstructure and articular cartilage in the osteoarthritic knee using 3T MRI
Chenglei Liu1, Chang Liu2, Liping Si1
1Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Background:
The importance of subchondral bone in the pathogenesis of osteoarthritis (OA) has drawn interest.
Purpose:
To investigate subregional trabecular bone microstructural features and to determine the relationship between cartilage and trabecular bone in the osteoarthritic human knee.
Study Type:
Prospective study.
Subjects:
In all, 92 knees were enrolled and divided into three groups: without OA, mild OA, and severe OA.
Sequence:
A sagittal 3D balanced fast field echo (3D B-FFE) sequence and FatSat 3D fast field echo (3D-FFE) sequence at 3T MRI.
Assessment:
The trabecular bone in 12 sites of the knee joint was evaluated using digital topological analysis, and the cartilage thickness in four sites was calculated.
Statistical Test:
Trabecular bone and cartilage parameters between groups were compared using analysis of variance (ANOVA) with Bonferroni adjustment, and their correlations were analyzed using Pearson's correlation coefficient.
Results:
Within both femoral condyles, the trabecular bone structure deteriorated in mild OA, showing a lower bone volume fraction (BVF) (0.15 to 0.12, P < 0.05), higher erosion index (EI) (2.25 to 2.28, P < 0.01), and a lower plate-to-rod ratio (SCR) (6.22 to 5.96, P < 0.05). Within medial and lateral tibia, deterioration in the trabecular bone was also observed, demonstrating a lower BVF (0.15 to 0.12 P < 0.05) and a higher EI (2.25 to 2.61, P < 0.05). Cartilage attrition mainly occurred in the medial joint. Extensive correlations were found between the medial cartilage thickness and subregional trabecular parameters. There was mainly a positive correlation with both femoral BVFs (r > 0.3, P < 0.05), and a negative correlation with the tibia SCR (r < -0.2, P < 0.05).
Data Conclusion:
In the early stage of OA, trabecular bone osteoporotic changes were observed in both femoral condyles and the tibia. Based on a strong correlation with the medial cartilage thickness, the trabecular structural topological analysis may be useful for elucidating OA onset and progression.
Level Of Evidence:
2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.
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