Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Contractile Ring02:15

The Contractile Ring

7.3K
Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
7.3K
Epithelial Tissues and Their Functions01:23

Epithelial Tissues and Their Functions

41.4K
Epithelial tissues are large sheets of cells covering all of the surfaces of the body. These surfaces can be internal or external, for example, skin, airways, the digestive tract, the urinary system, and the reproductive system. Hollow organs and body cavities that do not connect to the body's exterior, including blood vessels and serous membranes, are lined by epithelial tissue known as the endothelium.
Epithelial tissues provide the body's first line of protection from physical,...
41.4K
Functions of Connective Tissues01:17

Functions of Connective Tissues

17.3K
Connective tissues perform a broad range of functions in the body. Their primary function is to connect and link different tissues in the body and act as packaging material between tissues. The areolar tissue, a connective tissue prototype, commonly cements various tissue types in diverse body organs. In contrast, adipose tissue cushions internal organs while insulating the body from heat loss.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
17.3K
Tissues01:18

Tissues

85.8K
Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
85.8K
Construction of Root Locus01:15

Construction of Root Locus

431
The construction of a root locus involves several key steps to analyze and visualize the behavior of a system's poles with varying gain. The number of branches in the root locus equals the number of closed-loop poles and is symmetrical about the real axis.
For positive gain values, the root locus exists on the real axis to the left of an odd number of finite open-loop poles or zeros. The root locus starts at the open-loop poles and traces the paths of the closed-loop poles as the gain...
431
Construction of Frequency Distribution01:15

Construction of Frequency Distribution

12.9K
A frequency distribution table can be constructed using the steps given below.
First, make a table with two columns—one with the title of the data that needs to be organized, and the other column for frequency. [Draw a third column for tally marks if needed]. Then, take a look at the items given in the data set and decide if an ungrouped frequency distribution table or a grouped frequency distribution table would be more suitable. If there are large sets of different values, then it is...
12.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A tunable hydrogel system for long-term release of cell-secreted cytokines and bioprinted in situ wound cell delivery.

Journal of biomedical materials research. Part B, Applied biomaterials·2016
Same author

Re: A Tumor Mitochondria Vaccine Protects against Experimental Renal Cell Carcinoma.

The Journal of urology·2016
Same author

Re: Endogenous Formaldehyde is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.

The Journal of urology·2016
Same author

Re: Sphaeropsidin A Shows Promising Activity against Drug-Resistant Cancer Cells by Targeting Regulatory Volume Increase.

The Journal of urology·2016
Same author

Re: Sex Hormone-Dependent tRNA Halves Enhance Cell Proliferation in Breast and Prostate Cancers.

The Journal of urology·2016
Same author

Re: Mutations in TERT Promoter and FGFR3 and Telomere Length in Bladder Cancer.

The Journal of urology·2016

Related Experiment Video

Updated: Feb 14, 2026

Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting
04:40

Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting

Published on: July 2, 2017

10.9K

3D bioprinted functional and contractile cardiac tissue constructs.

Zhan Wang1, Sang Jin Lee1, Heng-Jie Cheng1

  • 1Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

Acta Biomaterialia
|February 17, 2018
PubMed
Summary

This study demonstrates the feasibility of 3D bioprinting functional cardiac tissue for myocardial regeneration and drug testing. The engineered cardiac tissue exhibits synchronous contraction and physiological responses, paving the way for advanced regenerative medicine and pharmaceutical applications.

Keywords:
BioprintingBody-on-a-chipCardiac tissueContractilityHeart failureIn vitro tissue modelTissue engineering

More Related Videos

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
08:34

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

17.4K
3D Bioprinting of Murine Cortical Astrocytes for Engineering Neural-Like Tissue
08:57

3D Bioprinting of Murine Cortical Astrocytes for Engineering Neural-Like Tissue

Published on: July 16, 2021

7.1K

Related Experiment Videos

Last Updated: Feb 14, 2026

Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting
04:40

Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting

Published on: July 2, 2017

10.9K
Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
08:34

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

17.4K
3D Bioprinting of Murine Cortical Astrocytes for Engineering Neural-Like Tissue
08:57

3D Bioprinting of Murine Cortical Astrocytes for Engineering Neural-Like Tissue

Published on: July 16, 2021

7.1K

Area of Science:

  • Bioengineering
  • Regenerative Medicine
  • Bioprinting

Background:

  • Cardiovascular disease is a leading cause of death, with myocardial infarction leading to permanent cardiac cell death and reduced heart function.
  • Current treatments like heart transplantation and ventricular assist devices have limitations due to organ shortage and complications.
  • Three-dimensional (3D) bioprinting offers a promising strategy to create clinically applicable cardiac tissue constructs.

Purpose of the Study:

  • To develop a contractile cardiac tissue with cellular organization, uniformity, and scalability using a 3D bioprinting strategy.
  • To assess the potential of bioprinted cardiac tissue for myocardial regeneration and in vitro tissue modeling.
  • To evaluate the physiological responses and maturation of engineered cardiac tissue.

Main Methods:

  • Primary cardiomyocytes were isolated from infant rat hearts and suspended in a fibrin-based bioink.
  • A 3D bioprinting strategy was employed using a sacrificial hydrogel and a supporting polymeric frame.
  • Immunostaining and drug response assays were used to confirm tissue development and functionality.

Main Results:

  • Bioprinted cardiac tissue constructs exhibited spontaneous synchronous contraction in culture.
  • Immunostaining confirmed uniformly aligned, dense, and electromechanically coupled cardiac cells.
  • Constructs responded physiologically to cardiac drugs, and Notch signaling blockade accelerated tissue maturation.

Conclusions:

  • 3D bioprinting is a feasible strategy for engineering functional cardiac tissue with organized structure and physiological properties.
  • The engineered cardiac tissue holds potential for regenerative medicine applications and pharmaceutical testing.
  • This approach could lead to the development of patient-specific cardiac tissues for treating heart failure.