Correction to: Integrating multiple data sources (MUDS) for meta-analysis to improve patient-centered outcomes

Evan Mayo-Wilson1, Susan Hutfless2,3, Tianjing Li2

  • 1Center for Clinical Trials and Evidence Synthesis, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA. emw@jhu.edu.

Abstract

Insights

This protocol outlines a method for integrating multiple data sources (MUDS) to enhance meta-analysis for patient-centered outcomes research. The approach aims to improve the quality and applicability of research findings.

Area of Science:

  • Health Services Research
  • Biostatistics
  • Clinical Informatics

Background:

  • Patient-centered outcomes research (PCOR) is crucial for healthcare decision-making.
  • Existing meta-analysis methods face challenges in integrating diverse data types.
  • A standardized protocol is needed to leverage multiple data sources effectively.

Purpose of the Study:

  • To present a protocol for a methodological study on integrating multiple data sources (MUDS) for meta-analysis.
  • To enhance patient-centered outcomes research (PCOR) by improving meta-analytic techniques.
  • To establish a framework for synthesizing heterogeneous data in health research.

Main Methods:

  • The study proposes a protocol for a methodological investigation.
  • It details procedures for data extraction, harmonization, and statistical analysis from varied sources.
  • The protocol emphasizes the integration of real-world data and clinical trial data.

Main Results:

  • This is a protocol paper; main results will be generated upon study completion.
  • The proposed methodology is expected to yield more robust and comprehensive meta-analytic results.
  • Anticipated outcomes include improved precision and generalizability of findings in PCOR.

Conclusions:

  • The MUDS protocol offers a novel approach to meta-analysis in PCOR.
  • Successful implementation can lead to more reliable evidence synthesis.
  • This methodological advancement supports better-informed healthcare decisions.

Related Concept Videos

Patient-centered Care01:13

Patient-centered Care

Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.1K
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
15.2K
Multiple Voltage Sources01:25

Multiple Voltage Sources

Generally, a single battery is not enough to power some devices. In such cases, batteries can be combined in two ways: in series or in parallel.
In series, the positive terminal of one battery is connected to the negative terminal of another battery. Hence, the voltage of each battery is added to give the net voltage, which is increased because each battery boosts the electrons that enter it. The same current flows through each battery because they are connected in series.
Batteries are...
1.8K
Applications of Integration to Find Centers of Mass01:30

Applications of Integration to Find Centers of Mass

Rotational equilibrium provides a natural framework for defining the center of mass of a system. For a plank balanced on a pivot with two unequal masses, equilibrium is achieved when the net torque about the pivot is zero. Torque is defined as the product of a force and its perpendicular distance from the pivot. When the torques due to all forces cancel, the pivot coincides with the center of mass of the system.For a system composed of several discrete point masses, the center of mass lies at...
89
GIS Software, Hardware, and Sources of GIS Data01:23

GIS Software, Hardware, and Sources of GIS Data

A Geographic Information System (GIS) combines specialized software and hardware to effectively manage, analyze, and present spatial and related data. GIS software includes critical functionalities such as a user interface for easy navigation, database management tools for handling spatial and attribute data, and data retrieval features for efficient access. Analytical tools transform raw data into insights, while display functions produce maps and reports in various formats for effective...
830
Mesh Analysis with Current Sources01:10

Mesh Analysis with Current Sources

Mesh analysis becomes simpler when analyzing circuits with current sources, whether independent or dependent. The presence of current sources reduces the number of equations required for analysis. Two cases illustrate this:
Current Source in One Mesh: The analysis process is straightforward when a current source is found in only one mesh within the circuit. Mesh currents are assigned as usual, with the mesh containing the current source excluded from the analysis. Kirchhoff's voltage law...
2.1K