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Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
Published on: November 23, 2012
Fever of Unknown Origin: the Value of FDG-PET/CT
Ilse J E Kouijzer1, Catharina M Mulders-Manders1, Chantal P Bleeker-Rovers1
1Department of Internal Medicine and Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
Abstract:
Fever of unknown origin (FUO) is commonly defined as fever higher than 38.3°C on several occasions during at least 3 weeks with uncertain diagnosis after a number of obligatory investigations. The differential diagnosis of FUO can be subdivided in four categories: infections, malignancies, noninfectious inflammatory diseases, and miscellaneous causes. In most cases of FUO, there is an uncommon presentation of a common disease. FDG-PET/CT is a sensitive diagnostic technique for the evaluation of FUO by facilitating anatomical localization of focally increased FDG uptake, thereby guiding further diagnostic tests to achieve a final diagnosis. FDG-PET/CT should become a routine procedure in the workup of FUO when diagnostic clues are absent. FDG-PET/CT appears to be a cost-effective routine imaging technique in FUO by avoiding unnecessary investigations and reducing the duration of hospitalization.
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