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Investigation of Genetic Dependencies Using CRISPR-Cas9-based Competition Assays
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Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2

Dongxin Zhao1, Mehmet G Badur1, Jens Luebeck2

  • 1Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.

Molecular Cell
|February 18, 2018
PubMed

Keywords:
KEAP1NADPHNRF2combinatorial CRISPR screeninggenetic interactionsglycolysismetabolic enzyme compensationmetabolic enzyme essentialitymetabolic flux analysisredox metabolism

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