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Published on: January 18, 2018
What is the optimal management of older CLL patients?
1The Ohio State University Division of Hematology, 445D Wiseman Hall CCC, 410 W 12th Ave, Columbus, OH 43210, USA.
Abstract:
CLL is the most common leukemia in older adults with a median age at diagnosis of 71. Therefore, management of patients with this disease must take into account the older age of most patients and consequences of this in terms of functional status and organ function. This review will discuss the management of CLL with regards to observation prior to the initiation of therapy, functional status, and initial treatment. We will discuss criteria for the initiation of therapy, and how initial therapy is different between older and younger patients. Finally, we will discuss specific therapies including chemoimmunotherapy and newer targeted therapies that are being used widely in the older patient population.
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