Related Experiment Video

Updated: Feb 14, 2026

Measuring the Switch Cost of Smartphone Use While Walking
07:00

Measuring the Switch Cost of Smartphone Use While Walking

Published on: April 30, 2020

2.3K

To switch from Botox to Dysport in children with CP, a real world, dose conversion, cost-effectiveness study

Kristina Tedroff1, Gustaf Befrits2, Carl Johan Tedroff3

  • 1Neuropediatric Unit Q202, Astrid Lindgren Children's Hospital, 171 76, Stockholm, Sweden; Neuropediatric Unit, Department of Women's and Children's Health, Q207, Karolinska Institutet, 171 76, Stockholm, Sweden.

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
|February 18, 2018
PubMed

Insights

Switching from Botox to Dysport for children with cerebral palsy (CP) using a 1:2 dose conversion was found to be equally effective and reduced drug costs by 41%. This study offers valuable insights for managing CP treatment costs and efficacy.

Area of Science:

  • Neurology
  • Pediatrics
  • Pharmacoeconomics

Background:

  • Children with cerebral palsy (CP) often receive botulinum toxin A (BoNT-A) injections.
  • Two commonly used BoNT-A products, Botox and Dysport, differ in price and dose equivalence.
  • Previous dose conversion studies lacked pediatric data, necessitating research in this population.

Purpose of the Study:

  • To compare the efficacy, duration, and side-effects of switching from Botox to Dysport in children with CP at a 1:2 conversion ratio.
  • To evaluate the impact of this switch on drug acquisition costs.

Main Methods:

  • A prospective, real-world, cost-effectiveness, population-based observational study.
  • Included 159 children with CP in the Stockholm area treated between September 2014 and December 2015.
  • Parental reports on efficacy, duration, and side-effects; physician reports on doses and goals; and drug acquisition costs were collected.

Main Results:

  • Caregivers reported comparable efficacy and duration of treatment with both products.
  • Side-effects were few, similar, and transient across both Botox and Dysport treatments.
  • Drug costs per treatment were significantly lower for Dysport (2380 SEK) compared to Botox (4029 SEK).

Conclusions:

  • A 1:2 unit dose conversion from Botox to Dysport in children with CP was perceived as equally effective by parents.
  • This switch resulted in a 41% reduction in drug costs based on procured prices.
  • The findings support the use of Dysport as a cost-effective alternative for BoNT-A treatment in pediatric CP management.
Abstract

Keywords:
Botulinum toxin ACerebral palsyChildrenDose equivalenceParent reported outcomeReal world

More Related Videos

Studying Brain Function in Children Using Magnetoencephalography08:00

Studying Brain Function in Children Using Magnetoencephalography

Published on: April 8, 2019

9.6K
Experimental Paradigm for Measuring the Effects of Self-distancing in Young Children07:01

Experimental Paradigm for Measuring the Effects of Self-distancing in Young Children

Published on: March 1, 2019

8.5K

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
335
IV Infusion to Oral Dosing: Conversion Methods01:28

IV Infusion to Oral Dosing: Conversion Methods

The development of extended-release formulations has facilitated the transition from intravenous to oral medication, offering a more convenient and patient-friendly approach to drug administration. This transition, however, requires careful management to ensure that therapeutic drug levels are maintained, preserving efficacy and avoiding adverse effects. Understanding pharmacokinetic principles and dosage calculations is critical during this process.Pharmacokinetics of the...
11
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
10.7K
Gene Conversion02:08

Gene Conversion

3.1K
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
850
Switching of BJT01:22

Switching of BJT

Switching behavior in Bipolar Junction Transistors (BJTs) is a fundamental aspect utilized in various electronic circuits, particularly for digital logic applications like switches and amplifiers. In a typical switching circuit, a BJT alternates between cut-off and saturation modes, corresponding to the "off" and "on" states, respectively, thus behaving like an ideal switch.
Cut-off Mode ("Off" State): In this state, both the emitter-base and collector-base junctions are...
897