Related Experiment Video
Updated: Feb 14, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
Published on: June 7, 2015
Radiation Therapy as an Effective Salvage Strategy for Secondary CNS Lymphoma
Sarah A Milgrom1, Chelsea C Pinnix1, T Linda Chi2
1Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Purpose:
We assessed the efficacy of radiation therapy (RT) in the management of secondary central nervous system (CNS) lymphoma.
Methods And Materials:
The cohort comprised 44 patients with systemic diffuse large B-cell lymphoma (DLBCL) secondarily involving the brain and/or leptomeninges at initial diagnosis or relapse that was treated with RT.
Results:
Of these patients, 29 (66%) were in systemic remission when CNS disease was diagnosed. The overall response rate to RT by magnetic resonance imaging was 88% (42% complete, 46% partial). The median overall survival (OS) after RT initiation was 7 months (95% confidence interval 4-10 months). The OS curve plateaued at 31% from 2 to 8 years. OS was superior in patients who achieved a complete or partial response to RT, underwent stem cell transplantation after RT, and had brain parenchymal (vs leptomeningeal) disease. Eight cases of CNS disease progression occurred after RT: 1 involved the brain parenchyma, and 7 involved the spine and/or cerebrospinal fluid and/or meninges.
Conclusions:
We conclude that RT is associated with high response rates and may contribute to long-term OS. In addition, RT may provide CNS disease control that facilitates successful salvage with stem cell transplantation in patients with chemotherapy-refractory disease.
Related Concept Videos
Biological Effects of Radiation
Secondary Active Transport
Secondary Healthcare System
Gene Therapy
Radiation: Applications
The average...
Primary and Secondary Growth in Roots and Shoots

