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[Down's syndrome in the Netherlands].

T W Hustinx, J M Scheres, J P Geraedts

    Tijdschrift Voor Kindergeneeskunde
    |August 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    This study found a lower-than-expected frequency of Down syndrome (DS) in older mothers. This suggests underreporting of DS cases in older maternal age groups, particularly those aged 40 and above.

    Area of Science:

    • Genetics and Genomics
    • Epidemiology
    • Reproductive Health

    Context:

    • Analysis of 348 patients with Down syndrome (DS) born in the Netherlands between 1981-1982.
    • Inclusion of prenatal and postnatal chromosome study data up to December 1984.
    • Comparison with a reference group from five comparable epidemiological studies.

    Purpose:

    • To determine Down syndrome (DS) rates across different maternal age groups.
    • To compare observed DS frequencies with established epidemiological data.
    • To investigate potential underdiagnosis or underreporting in specific maternal age demographics.

    Summary:

    • DS rates were calculated for five-yearly maternal age classes.
    • A notably lower frequency of DS was observed in mothers aged 40 years and older compared to reference data.

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  • It is hypothesized that DS cases in older maternal age groups (40-44 and ≥45) may be underreported or not yet referred for cytogenetic analysis.

    • Impact:

    • Highlights the need for improved ascertainment and reporting of Down syndrome (DS) cases, especially in older maternal populations.
    • Suggests potential biases in epidemiological data collection related to maternal age.
    • Informs future research on DS prevalence and diagnostic practices across diverse demographic groups.