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Updated: Feb 14, 2026

Introduction to the Ultrasound Targeted Microbubble Destruction Technique
Published on: June 12, 2011
Antibacterial Weapons: Targeted Destruction in the Microbiota
Benoit Chassaing1, Eric Cascales2
1Neuroscience Institute, Georgia State University, Atlanta, GA, USA; Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Abstract:
The intestinal microbiota plays an important role in health, particularly in promoting intestinal metabolic capacity and in maturing the immune system. The intestinal microbiota also mediates colonization resistance against pathogenic bacteria, hence protecting the host from infections. In addition, some bacterial pathogens deliver toxins that target phylogenetically related or distinct bacterial species in order to outcompete and establish within the microbiota. The most widely distributed weapons include bacteriocins, as well as contact-dependent growth inhibition and type VI secretion systems. In this review, we discuss important advances about the impact of such antibacterial systems on shaping the intestinal microbiota.
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