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Clonal selection drives protective memory B cell responses in controlled human malaria infection

Rajagopal Murugan1, Lisa Buchauer2,3,4, Gianna Triller1

  • 1B Cell Immunology, German Cancer Research Center, Heidelberg, Germany.

Science Immunology
|February 18, 2018
PubMed
Summary

Repeated exposure to malaria parasite (Plasmodium falciparum) boosts B cell memory responses. Clonal selection of B cell precursors, rather than affinity maturation, drives memory development against complex antigens like PfCSP.

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