Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Declination01:19

Magnetic Declination

493
Magnetic declination is the angle between true north, which aligns with the Earth's rotational axis, and magnetic north, which follows the direction of the Earth's magnetic field. This discrepancy exists because the magnetic poles do not coincide with the geographic poles. The value of magnetic declination depends on the observer's location on Earth and is subject to changes over time due to the dynamic nature of the Earth's magnetic field.The declination is called eastern when magnetic north...
493
Cognitive Theories: Lazarus Mediational Theory of Emotion01:17

Cognitive Theories: Lazarus Mediational Theory of Emotion

2.2K
Richard Lazarus' cognitive mediational theory highlights the pivotal role of cognitive appraisal in shaping emotional responses. According to this theory, the evaluation of a stimulus — based on personal values, goals, beliefs, and expectations — mediates the emotional response. This appraisal process is immediate and often occurs unconsciously, influencing the intensity and nature of the resulting emotion.
Cognitive Appraisal and Emotional Response
Lazarus proposed that...
2.2K
Conservation of Declining Populations02:07

Conservation of Declining Populations

13.4K
Conservation of declining population focuses on ways of detecting, diagnosing, and halting a population decline. The approach uses methods to prevent populations from going extinct.
13.4K
Cognitive Dissonance01:38

Cognitive Dissonance

37.5K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.7K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.7K
Paracrine Signaling01:21

Paracrine Signaling

59.7K
Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
59.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Examining the Causal Relationship Between Hikikomori and Psychological Features of New-Type Depression: A Longitudinal Study on Male Individuals With Hikikomori Condition.

The International journal of social psychiatry·2026
Same author

Interleukin-6 levels decrease following rituximab treatment but increase following tocilizumab treatment.

Annals of hematology·2026
Same author

Comparative Network Structures of Hikikomori (Social Withdrawal) Symptoms in Korean and Japanese Psychiatric Patients Prescribed Antidepressants: Findings From the Research on Asian Psychotropic Patterns for Antidepressants, Phase 3.

Journal of Korean medical science·2026
Same author

Improved prognosis prediction of all-cause mortality and cardiovascular events by combined assessment of both ankle-brachial index and brachial-ankle pulse wave velocity in individuals with diabetes: The Kyushu prevention study for atherosclerosis, a prospective, multicenter survey.

Journal of diabetes investigation·2026
Same author

CAT-Hokkaido: A tablet-based assessment of cognitive impairment in schizophrenia.

PCN reports : psychiatry and clinical neurosciences·2026
Same author

β-Hydroxybutyrate modulates intestinal barrier function and visceral sensitivity via a brain AMPK-orexin pathway recruiting histamine H1 receptors, basal forebrain cholinergic neurons, adenosine A2B receptors, and vagal output in rats.

Biochemical pharmacology·2026
Same journal

A tri-axis optomechanical accelerometer with plasmonic MIM waveguide and structural direction-dependent optical signatures.

Scientific reports·2026
Same journal

Holographic leaky-wave antennas with independently controlled multiple counter-rotating vortex beams.

Scientific reports·2026
Same journal

Differential associations of longitudinal hearing and vision trajectories with dementia and mild cognitive impairment in older adults.

Scientific reports·2026
Same journal

Abdominal obesity and leisure-time sedentary behavior in relation to gastroesophageal reflux disease risk: a prospective cohort study from the UK Biobank.

Scientific reports·2026
Same journal

Effect of nitrogen-rich COF incorporation on the structure and separation performance of polyamide nanofiltration membranes.

Scientific reports·2026
Same journal

Withanolide A inhibits hIAPP aggregation: An In silico, biophysical, and drosophila-based In vivo validation.

Scientific reports·2026
See all related articles

Related Experiment Video

Updated: Feb 14, 2026

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

6.9K

p66Shc Signaling Mediates Diabetes-Related Cognitive Decline.

Yohei Minami1, Noriyuki Sonoda2,3, Eiichi Hayashida1

  • 1Department of Internal Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Scientific Reports
|February 18, 2018
PubMed
Summary
This summary is machine-generated.

Diabetes causes cognitive decline through oxidative stress, independent of Alzheimer's disease pathology. Targeting the p66Shc pathway may prevent this brain damage.

More Related Videos

Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer
16:59

Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer

Published on: October 10, 2012

12.2K
Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

3.3K

Related Experiment Videos

Last Updated: Feb 14, 2026

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

6.9K
Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer
16:59

Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer

Published on: October 10, 2012

12.2K
Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

3.3K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Pathology

Background:

  • Diabetes mellitus is increasingly linked to dementia, including Alzheimer's disease (AD).
  • Oxidative stress (OS) is implicated in diabetic complications, but its role in diabetes-associated cognitive decline is not fully understood.
  • The specific mechanisms linking diabetes to brain damage, independent of AD pathology, require further elucidation.

Purpose of the Study:

  • To investigate the role of the p66Shc signaling pathway in diabetes-related cognitive decline.
  • To determine if oxidative stress and brain damage in a diabetic model are mediated through AD-independent mechanisms.
  • To explore the potential of targeting the p66Shc pathway for mitigating diabetes-induced cognitive impairment.

Main Methods:

  • Utilized p66Shc knockout (-/-) mice in a diabetic animal model.
  • Assessed levels of oxidative stress (OS) in the brain.
  • Evaluated cognitive function and brain damage.
  • Quantified microglial activation.

Main Results:

  • p66Shc knockout mice exhibited reduced brain OS and resistance to diabetes-induced brain damage.
  • Diabetic p66Shc knockout mice showed significantly less cognitive dysfunction compared to wild-type diabetic mice.
  • Reduced OS and microglial activation were observed in p66Shc knockout diabetic mice.

Conclusions:

  • The p66Shc signaling pathway contributes to diabetes-associated cognitive impairment.
  • Oxidative stress, mediated by p66Shc, plays a key role in diabetes-induced brain damage independently of amyloid-β accumulation.
  • A p66Shc-mediated inflammatory cascade leading to OS is a potential pathogenic mechanism in diabetes-related cognitive decline.