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Assessment of Child Anthropometry in a Large Epidemiologic Study
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IGF-I and IGFBP-3 concentrations at 2 years: associations with anthropometry and milk consumption in an Indian cohort

Andrea S Wiley1, Suyog M Joshi2, Himangi G Lubree2

  • 1Anthropology Department and Human Biology Program, Indiana University, Bloomington, IN, USA. wileya@indiana.edu.

European Journal of Clinical Nutrition
|February 18, 2018
PubMed

Insights

Plasma insulin-like growth factor I (IGF-I) and its ratio with IGFBP-3 at age two are linked to longer child length and higher milk consumption. These findings highlight the role of IGF-I in early childhood growth and diet in an Indian cohort.

Area of Science:

  • Pediatric Endocrinology
  • Human Growth and Development
  • Nutritional Science

Background:

  • Investigating the relationship between insulin-like growth factor I (IGF-I), insulin-like growth factor-binding protein 3 (IGFBP-3), and their molar ratio with early life factors.
  • Understanding the impact of neonatal size, infant growth, and body composition on these biomarkers.
  • Examining the influence of feeding practices on IGF-I and IGFBP-3 levels in an Indian population.

Purpose of the Study:

  • To determine associations between plasma IGF-I, IGFBP-3, and their molar ratio at 2 years of age.
  • To correlate these biomarkers with neonatal size, infant growth, and body composition at 2 years.
  • To explore the relationship between feeding practices and these growth factors in Indian children.

Main Methods:

  • A cohort of 209 newborns was followed, with 122 assessed at 2 years.
  • Anthropometry, plasma IGF-I, and IGFBP-3 concentrations were measured at birth and 2 years.
  • Maternal and child diet was assessed using food frequency questionnaires and interviews; multivariate regression was employed for analysis.

Main Results:

  • Plasma IGF-I and the IGF-I/IGFBP-3 ratio at 2 years were positively associated with length at 2 years, but not BMI or adiposity.
  • Higher IGF-I concentrations were observed in children with greater length change, higher milk intake, and those whose mothers consumed milk during pregnancy.
  • IGFBP-3 showed no significant relationship with anthropometry or milk intake.

Conclusions:

  • Plasma IGF-I concentrations and the IGF-I/IGFBP-3 ratio at 2 years are positively associated with length at 2 years.
  • Current milk intake is also positively associated with 2-year IGF-I levels and the IGF-I/IGFBP-3 ratio.
  • These findings suggest a link between IGF-I, growth, and milk consumption in early childhood.
Abstract

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