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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Kidney Transplant III: Nursing Management01:16

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Kidney Structure01:45

Kidney Structure

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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What is the Immune System?01:38

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Humoral Immune Responses01:36

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Immune System and Kidney Transplantation.

Badri Man Shrestha1

  • 1Division of Renal Transplantation, Sheffield Kidney Institute, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom.

JNMA; Journal of the Nepal Medical Association
|February 18, 2018
PubMed
Summary

Kidney transplant rejection occurs when the immune system attacks the new organ. Immunosuppressive drugs help prevent this, improving transplant success rates.

Area of Science:

  • Immunology
  • Transplantation Medicine
  • Nephrology

Background:

  • The human immune system identifies transplanted kidneys as foreign, triggering cellular and humoral responses that can lead to rejection and graft loss.
  • Significant progress in understanding immune responses to transplanted organs has been made over the past 50 years.
  • Immunosuppressive therapy is crucial for successful kidney transplantation outcomes.

Purpose of the Study:

  • To provide an overview of the human immune system's organization and function.
  • To explain the immune response specifically related to kidney transplantation.
  • To review current immunosuppressive therapy practices in the United Kingdom for kidney transplants.

Main Methods:

  • Literature review of immunological principles.
Keywords:
immune; kidney; system; transplantation.

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  • Analysis of immune mechanisms in kidney transplant rejection.
  • Review of clinical practices and immunosuppressive strategies in the UK.

    • Main Results:

    • The immune system's recognition of foreign antigens initiates rejection pathways.
    • Effective immunosuppression strategies have improved graft survival rates.
    • Current UK practices involve tailored immunosuppressive regimens.

    Conclusions:

    • Understanding the immune system is key to managing kidney transplant rejection.
    • Immunosuppressive therapy remains the cornerstone of successful kidney transplantation.
    • The review highlights the importance of current immunosuppressive protocols in the UK context.