Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Homeostatic Imbalance01:10

Homeostatic Imbalance

36.0K
Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
However, sometimes these feedback loops fail,...
36.0K
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

3.3K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.3K
Oxidation Numbers03:14

Oxidation Numbers

43.3K
In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
43.3K
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

4.2K
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
4.2K
Pyruvate Oxidation01:15

Pyruvate Oxidation

169.5K
After glycolysis, the charged pyruvate molecules enter the mitochondria via active transport and undergo three enzymatic reactions. These reactions ensure that pyruvate can enter the next metabolic pathway so that energy stored in the pyruvate molecules can be harnessed by the cells.
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
169.5K
Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

1.7K
Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SLC30A1, SLC30A5, and SLC30A9 transporters play crucial role in ligand-independent activation of ESR1 signalling in breast cancer cells via modulation of AKT activity by zinc.

Metallomics : integrated biometal science·2026
Same author

Citrate silver nanoparticles modulate estrogen signaling in estradiol-supplemented ER-positive breast cancer cells.

Molecular and cellular endocrinology·2026
Same author

Porous Curdlan-Whey Protein Isolate Scaffolds Obtained by Combined Method for Cartilage Tissue Engineering Application.

Materials (Basel, Switzerland)·2026
Same author

Toxicity of High-Density Polyethylene Nanoparticles in Combination with Silver Nanoparticles to Caco-2 and HT29MTX Cells Growing in 2D or 3D Culture.

Molecules (Basel, Switzerland)·2026
Same author

Anthocyanin-Rich Blackcurrant Pomace Mitigates Oxidative Stress and Affects Steroid Metabolism in the Testes of Rats Exposed to Silver Nanoparticles.

Nutrients·2025
Same author

Silver and polystyrene nanoparticles activate oestrogen signalling via cytoplasmic oestrogen receptor.

Scientific reports·2025

Related Experiment Video

Updated: Feb 14, 2026

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance
06:42

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

2.9K

Nanoparticles-Caused Oxidative Imbalance.

Mariusz Zuberek1, Agnieszka Grzelak2

  • 1Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland. zuberekmariusz@gmail.com.

Advances in Experimental Medicine and Biology
|February 18, 2018
PubMed
Summary

Nanomaterials cause harm by inducing oxidative stress, leading to cell damage and various health issues. Understanding nanoparticle toxicity is crucial for human and environmental safety.

Keywords:
DNA damageNanoparticlesNanotoxicityOxidative stressROSSignal transduction

More Related Videos

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
08:26

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Published on: October 19, 2015

12.7K
Visible-light Induced Reduction of Graphene Oxide Using Plasmonic Nanoparticle
07:24

Visible-light Induced Reduction of Graphene Oxide Using Plasmonic Nanoparticle

Published on: September 22, 2015

14.9K

Related Experiment Videos

Last Updated: Feb 14, 2026

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance
06:42

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

2.9K
Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
08:26

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Published on: October 19, 2015

12.7K
Visible-light Induced Reduction of Graphene Oxide Using Plasmonic Nanoparticle
07:24

Visible-light Induced Reduction of Graphene Oxide Using Plasmonic Nanoparticle

Published on: September 22, 2015

14.9K

Area of Science:

  • Environmental Science
  • Toxicology
  • Materials Science

Background:

  • Nanomaterials are widely used across industries, leading to environmental and biological accumulation.
  • The precise toxicity of nanomaterials to humans and biota remains poorly understood.
  • Chronic exposure to nanoparticles is linked to numerous pathologies, including respiratory, cardiovascular, and immune system disorders, as well as cancer.

Purpose of the Study:

  • To investigate the nanoparticle-induced redox imbalance in cells.
  • To elucidate the cellular mechanisms underlying nanoparticle toxicity.
  • To explore the link between cellular redox state and organismal pathologies.

Main Methods:

  • Focus on the cellular level effects of nanomaterials.
  • Investigate the induction of oxidative stress by nanoparticles.
  • Analyze the disruption of cellular redox balance and reactive oxygen species (ROS) production.

Main Results:

  • Nanoparticles predominantly induce oxidative stress at the cellular level.
  • Imbalance in cellular redox state leads to excessive reactive oxygen species (ROS) production.
  • This imbalance can cause metabolic malfunctions and contribute to various pathologies.

Conclusions:

  • Nanoparticle-induced redox imbalance is a key mechanism of toxicity.
  • Excessive ROS production disrupts cellular signaling and function.
  • Further research is needed to fully understand and mitigate nanoparticle health risks.