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Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
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Evaluation of carotid artery elasticity in patients with uremia by echo tracking

Hong Liang1, Dawei Wang2, Guoying Che3

  • 1Ultrasound Department, Beijing Zhongguancun Hospital, 12 Zhongguancun Road, Beijing, 100080, China.

Journal of Medical Ultrasonics (2001)
|February 18, 2018
PubMed

Insights

Echo tracking (ET) reveals reduced carotid artery elasticity in uremia patients, even with normal intima-media thickness (IMT). This noninvasive method highlights early vascular changes in kidney disease.

Area of Science:

  • Vascular biology
  • Nephrology
  • Medical imaging

Background:

  • Uremia, a condition associated with kidney failure, can lead to significant cardiovascular complications.
  • Arterial stiffness is a known predictor of cardiovascular events and is often altered in patients with chronic kidney disease.

Purpose of the Study:

  • To compare carotid artery wall elasticity between patients with uremia and healthy controls using echo tracking (ET).
  • To assess various elasticity parameters and their correlation with intima-media thickness (IMT) in uremic patients.

Main Methods:

  • Ninety-three uremia patients and 35 controls underwent echo tracking (ET) to measure stiffness index (β), pressure-strain elasticity modulus (EP), arterial compliance (AC), and pulse wave velocity (PWVβ).
  • Carotid intima-media thickness (IMT) was measured using B-mode ultrasonography.
  • Patients were categorized into groups based on IMT and presence of atheroma plaques.

Main Results:

  • Uremia patients exhibited significantly higher stiffness index (β), pressure-strain elasticity modulus (EP), and pulse wave velocity (PWVβ) compared to controls (P < 0.05).
  • Arterial compliance (AC) was lower in uremia patients, though not statistically significant across all groups.
  • These elasticity changes were particularly pronounced in patients with thickened IMT or atheroma plaques.

Conclusions:

  • Echo tracking (ET) is a valuable noninvasive tool for detecting reduced carotid artery elasticity in uremia patients.
  • Loss of carotid artery elasticity can be observed even in uremic patients with normal intima-media thickness (IMT), indicating early vascular dysfunction.
Abstract

Keywords:
CarotidEcho trackingElasticityIntima–media thicknessUremia

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