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Updated: Feb 14, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Expression Level of miR-34a in Tumor Tissue from Patients with Esophageal Squamous Cell Carcinoma
Milad Asadi1, Dariush Shanehbandi1, Hanieh Mohammadpour1
1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Background:
miR-34a has been shown to be involved in P53 regulation. In this study, we aimed to evaluate the expression level of miR-34a in esophageal cancer and compare it with that of the normal marginal tissues.
Methods:
Tumor and marginal tissues were obtained from 50 patients with esophageal cancer. After RNA extraction, expression level of miR-34a was determined using SYBR green master mix and real-time quantitative PCR.
Results:
It was observed that there was a downregulation of miR-34a in tumoral tissue of esophageal patients in comparison to normal marginal tissues. Moreover, the expression level of miR-34a was correlated with clinicopathological specifications of the patients.
Conclusions:
miR-34a may be involved in the pathogenesis and development of esophageal cancer and have the potential to be used as a diagnostic and therapeutic marker in esophageal cancer.
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