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Fungal infections in patients with inflammatory bowel disease: A systematic review

George A Stamatiades1,2, Petros Ioannou1,3, George Petrikkos4

  • 1Infectious Diseases Working Group, Society of Junior Doctors, Athens, Greece.

Mycoses
|February 18, 2018
PubMed
Abstract

Insights

Fungal infections, primarily Candida, are common in inflammatory bowel disease (IBD) patients, often affecting the GI tract. Early detection and management are crucial for these patients.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Mycology

Background:

  • Fungal infections in inflammatory bowel disease (IBD) patients are reported but lack detailed clinical and microbiological characterization.
  • Understanding these infections is critical for patient management.

Purpose of the Study:

  • To systematically review existing evidence on fungal infections in patients with IBD.
  • To identify common fungal species, infection characteristics, and outcomes.

Main Methods:

  • A systematic literature search was conducted on PubMed up to May 2017.
  • Included studies provided data on clinical, microbiological, treatment, and outcome data of fungal infections in IBD patients.
  • Primary outcome: most common fungal species. Secondary outcomes: infection characteristics, IBD data, treatment, and outcomes.

Main Results:

  • Fourteen studies involving 1524 patients were analyzed.
  • Candida species were the most common cause of fungal infections (903 cases), predominantly in the gastrointestinal tract.
  • Infections often occurred within 12 months of IBD treatment, and within 6 months with anti-TNFa agents.

Conclusions:

  • This systematic review provides a comprehensive overview of fungal infections in IBD patients.
  • Findings offer valuable insights for early detection and improved management strategies.
  • Highlights the association between IBD treatments, particularly anti-TNFa agents, and the timing of fungal infections.
Keywords:
Crohn'sfungal infectioninflammatory bowel diseaseopportunisticsystematic reviewulcerative colitis

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