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MAPK and PI3K signaling: At the crossroads of neural crest development

Colin J Dinsmore1, Philippe Soriano1

  • 1Department of Cell, Developmental and Regenerative Biology, Tisch Cancer Institute, Icahn School of Medicine at Mt. Sinai, New York, NY 10029, USA.

Developmental Biology
|February 18, 2018
PubMed

Insights

Growth factor signaling via receptor tyrosine kinases is crucial for neural crest development. This review clarifies the roles of MAPK and PI3K pathways in these essential processes.

Area of Science:

  • Developmental Biology
  • Cell Signaling

Background:

  • Receptor tyrosine kinase (RTK) signaling regulates neural crest formation and development.
  • Downstream effectors, including MAPK and PI3K pathways, are frequently activated by RTK ligands.
  • Significant knowledge gaps exist regarding the precise spatiotemporal requirements and functional outcomes of these pathways in neural crest cells.

Purpose of the Study:

  • To review the current understanding of growth factor-induced MAPK and PI3K signaling in neural crest development.
  • To consolidate information on the roles and mechanisms of these critical signaling cascades.

Main Methods:

  • Literature review of studies investigating RTK, MAPK, and PI3K signaling in neural crest.
  • Synthesis of findings from genetic, molecular, and cell biology research.

Main Results:

  • MAPK and PI3K pathways are central to RTK-mediated growth factor signaling in the neural crest.
  • These pathways integrate signals from various ligands and receptors.
  • Specific requirements and functions of these pathways remain areas of active investigation.

Conclusions:

  • Understanding MAPK and PI3K signaling in the neural crest is vital for comprehending development and potential therapeutic interventions.
  • Further research is needed to delineate the precise roles and regulation of these pathways.
Keywords:
AKTCell signalingERKReceptor Tyrosine kinases

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