Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Oral Cavity

Oral Cavity

The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...

What is Natural Selection?

What is Natural Selection?

Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.

Antibiotic Selection

Antibiotic Selection

Types of Selection

Types of Selection

Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...

Frequency-dependent Selection

Frequency-dependent Selection

When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.

Oral Hypoglycemic Agents: Glinides

Oral Hypoglycemic Agents: Glinides

Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

High-throughput identification of bacterial β-glucuronidase inhibitors using machine learning.

Gut microbes·2026

Same author

Melatonin-loaded 3D-printed carboxymethyl cellulose-gold nanoparticles composite hydrogels for wound healing.

International journal of biological macromolecules·2026

Same author

Microbubbles manufactured using a tissue homogeniser: DoE-guided optimisation for a narrower size distribution and higher yield.

International journal of pharmaceutics·2026

Same author

Artificial intelligence-enabled personalisation of oral drug delivery: From data-driven design to on-demand manufacturing.

Advanced drug delivery reviews·2026

Same author

A multi-strain probiotic modulates gut microbiome composition, intestinal barrier integrity and inflammation in a multi-compartmental in vitro gut model of decompensated advanced chronic liver disease.

International journal of pharmaceutics·2026

Same author

Technical pen-based printhead for high-precision microdosing of personalized therapies.

Drug delivery and translational research·2026

Search research articles

Related Experiment Video

Updated: Feb 14, 2026

Stereolithographic 3D Printing with Renewable Acrylates

Stereolithographic 3D Printing with Renewable Acrylates

Published on: September 12, 2018

Fabricating 3D printed orally disintegrating printlets using selective laser sintering.

Fabrizio Fina¹, Christine M Madla¹, Alvaro Goyanes²

¹Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.

International Journal of Pharmaceutics

|February 18, 2018

Summary

This summary is machine-generated.

Selective laser sintering (SLS) enables the creation of 3D printed tablets with rapid drug release. This technology can produce orally disintegrating formulations, offering new possibilities for pharmaceutical manufacturing.

Keywords:

Additive manufacturing Orally disintegrating tablets Personalised medicines Rapid prototyping Three-dimensional printing

More Related Videos

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Published on: May 19, 2022

Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds

Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds

Published on: April 2, 2018

Related Experiment Videos

Last Updated: Feb 14, 2026

Stereolithographic 3D Printing with Renewable Acrylates

Stereolithographic 3D Printing with Renewable Acrylates

Published on: September 12, 2018

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Published on: May 19, 2022

Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds

Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds

Published on: April 2, 2018

Area of Science:

Pharmaceutical Technology
Materials Science
Additive Manufacturing

Background:

Selective Laser Sintering (SLS) is an additive manufacturing technique.
Current limitations exist in developing solid dosage forms with tailored drug release profiles.

Purpose of the Study:

To explore the feasibility of SLS for fabricating 3D printed tablets (printlets).
To investigate the potential of SLS to create formulations with accelerated drug release and orally disintegrating properties.

Main Methods:

Two polymers, hydroxypropyl methylcellulose (HPMC E5) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA 64), were mixed with paracetamol and a colorant.
Powder mixtures were processed using SLS 3D printing to create printlets.
SLS printing parameters, specifically laser scanning speed, were modulated to influence drug release.
X-ray micro-CT analysis was used to assess printlet density and porosity.

Main Results:

SLS successfully fabricated paracetamol-loaded printlets.
Modulating laser scanning speed altered drug release kinetics, with faster speeds accelerating release.
Kollidon VA 64 printlets printed at 300 mm/s demonstrated rapid oral disintegration (<4 seconds).
X-ray micro-CT revealed reduced density and increased porosity in orally disintegrating printlets.

Conclusions:

SLS 3D printing is a viable technology for manufacturing printlets with tunable drug release.
This study demonstrates the potential of SLS for creating orally disintegrating tablets.
SLS offers a promising platform for advanced pharmaceutical research and modern medicine manufacturing.