Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

14.7K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
14.7K
Lobes of the Cerebrum01:22

Lobes of the Cerebrum

4.8K
The cerebral cortex, a critical structure of the brain, is intricately divided into two hemispheres, each consisting of four distinct lobes: occipital, temporal, frontal, and parietal. These lobes function cooperatively to regulate various cognitive and sensory functions, forming the basis of our complex neural capabilities.
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements....
4.8K
Aging01:26

Aging

844
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
844
C4 Pathway and CAM01:27

C4 Pathway and CAM

49.4K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
49.4K
Three Developmental Domains01:29

Three Developmental Domains

1.2K
Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
1.2K
Membrane Domains01:18

Membrane Domains

7.3K
The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disruption of temporo-parietal network in Alzheimer's disease and its association with memory impairment.

Alzheimer's research & therapy·2026
Same author

Subtyping and staging of Alzheimer's disease from routine structural MRI with PHASE-AD.

medRxiv : the preprint server for health sciences·2026
Same author

Smartphone-based detection of subtle memory decline in prodromal Alzheimer's disease.

NPJ digital medicine·2026
Same author

The In Vivo Microstructural Profile of Human Hippocampal Subfield CA1 and Its Relation to Memory Performance.

Human brain mapping·2026
Same author

Dysfunction of the episodic memory network in the Alzheimer's disease cascade.

Nature communications·2026
Same author

Hallmarks of healthy cognitive aging: Inter-individual differences in aging trajectories.

Ageing research reviews·2026

Related Experiment Video

Updated: Feb 14, 2026

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures
12:30

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures

Published on: July 2, 2014

21.0K

Age-related functional changes in domain-specific medial temporal lobe pathways.

David Berron1, Katja Neumann1, Anne Maass2

  • 1Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany; German Center for Neurodegenerative Diseases, Magdeburg, Germany.

Neurobiology of Aging
|February 18, 2018
PubMed
Summary

Aging differentially impacts medial temporal lobe pathways for object and scene memory. Older adults show reduced domain-specific activity in the perirhinal cortex (PrC), affecting object mnemonic discrimination performance.

Keywords:
AgingEntorhinal cortexHippocampusMnemonic discriminationObjects and scenesPerirhinal cortexfMRI

More Related Videos

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.6K
Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

2.5K

Related Experiment Videos

Last Updated: Feb 14, 2026

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures
12:30

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures

Published on: July 2, 2014

21.0K
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.6K
Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

2.5K

Area of Science:

  • Neuroscience
  • Cognitive Psychology

Background:

  • The medial temporal lobes (MTLs) contain distinct pathways for processing object and scene information.
  • Anterior-lateral entorhinal cortex (alErC) is linked to object processing, while posterior-medial entorhinal cortex (pmErC) is linked to scene processing.

Purpose of the Study:

  • To investigate whether aging differentially affects the object and scene processing pathways in the MTL.
  • To examine the functional organization of MTL subregions during mnemonic discrimination of objects and scenes.

Main Methods:

  • Developed a mnemonic discrimination task involving objects and scenes.
  • Used functional magnetic resonance imaging (fMRI) in young and older adults.
  • Segmented MTL subregions, including alErC and pmErC, for functional activity analysis.

Main Results:

  • Object processing activated the perirhinal cortex (PrC) and alErC; scene processing activated parahippocampal cortex and pmErC.
  • Older adults performed worse on mnemonic discrimination but showed equivalent domain reductions.
  • Older adults exhibited reduced domain-specific activity in PrC, correlating with poorer object discrimination.

Conclusions:

  • The MTL is functionally organized into domain-specific pathways for object and scene mnemonic discrimination.
  • Aging differentially affects these MTL pathways, particularly impacting object processing in the PrC.
  • Future research should explore differential effects in early Alzheimer's disease stages.