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Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure
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Vascular parameters continue to decrease post-exposure with simultaneous, but not individual exposure to BPA and

Alysha D Cypher1, Bryce Fetterman1, Brian Bagatto1

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Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
|February 18, 2018
PubMed
Summary
This summary is machine-generated.

Bisphenol A (BPA) and hypoxia exposure in zebrafish larvae impairs red blood cell velocity, an effect that worsens over time even after exposure ends. This highlights BPA

Keywords:
Bisphenol ACardiovascularCo-exposureHIF-1αHypoxiaVascularZebrafish

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Area of Science:

  • Environmental toxicology
  • Cardiovascular physiology
  • Developmental biology

Background:

  • Hypoxia is a common environmental stressor affecting aquatic organisms.
  • Bisphenol A (BPA), a plasticizer, is a known cardiotoxin that disrupts the hypoxia-inducible factor pathway (HIF-1α).
  • Combined exposure to hypoxia and BPA causes bradycardia and reduced cardiac output in zebrafish larvae.

Purpose of the Study:

  • To investigate the concentration-dependent cardiovascular effects of co-exposure to BPA and hypoxia in zebrafish.
  • To determine the persistence of these cardiovascular effects after the exposure period.

Main Methods:

  • Zebrafish embryos were exposed to varying concentrations of BPA (0-100 μg/L) under normoxic and hypoxic conditions from 1-72/96 hours post fertilization.
  • Cardiovascular parameters, including heart rate, cardiac output, and red blood cell (RBC) velocity, were measured using video microscopy and digital motion analysis.
  • Measurements were taken at late hatching and 10 days post fertilization (dpf) to assess both immediate and long-term effects.

Main Results:

  • Exposure to 0.01 μg/L BPA with hypoxia significantly reduced RBC velocity by 25% at late hatching compared to hypoxic controls.
  • This reduction in RBC velocity doubled by 10 dpf, indicating persistent effects despite several days of recovery.
  • A 24% thinner caudal vein diameter was observed at 10 dpf, with statistical interactions noted between BPA and oxygen levels for arterial RBC velocity.

Conclusions:

  • Co-exposure to BPA and hypoxia has lasting detrimental effects on cardiovascular function in zebrafish larvae, particularly on RBC velocity.
  • The observed effects persist beyond the exposure period, suggesting potential long-term health implications.
  • Understanding the interaction between BPA and hypoxia is crucial given their common co-occurrence in aquatic environments.