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Low power lasers on genomic stability.

Larissa Alexsandra da Silva Neto Trajano¹, Luiz Philippe da Silva Sergio², Ana Carolina Stumbo³

¹Laboratório de Pesquisa em Células Tronco, Departamento de Histologia e Embriologia, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Avenida 28 de Setembro, 87, fundos, Vila Isabel, Rio de Janeiro 20551030, Brazil; Laboratório de Biomorfologia e Patologia Experimental, Mestrado Profissional em Diagnóstico Clínico e Laboratorial em Medicina Veterinária, Universidade Severino Sombra, Avenida Expedicionário Oswaldo de Almeida Ramos, 280, Vassouras, Rio de Janeiro 27700000, Brazil.

Journal of Photochemistry and Photobiology. B, Biology

|February 18, 2018

Summary

This summary is machine-generated.

Low power lasers may enhance cellular defenses against DNA damage by modulating DNA repair and telomere maintenance. This review explores their potential to improve therapeutic strategies against genotoxic agents.

Keywords:

Base excision repair Genomic stability Low power laser Nucleotide excision repair Telomere

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Area of Science:

Molecular Biology
Genetics
Biophysics

Background:

Genotoxic agents induce DNA modifications, leading to genomic instability.
Cells possess DNA damage responses, including base excision repair and nucleotide excision repair pathways, to counteract lesions.
Telomere shortening is linked to diseases like cancer, highlighting the importance of genomic and telomere stability.

Purpose of the Study:

To review the effects of low power lasers on genomic and telomere stabilization.
To explore the potential of low power lasers in improving therapeutic protocols against DNA-damaging agents.

Main Methods:

Review of existing studies on laser-induced effects on genome and telomere stabilization.
Analysis of how low power lasers modulate DNA repair mechanisms and telomere maintenance.

Main Results:

Low power laser exposure appears to modulate DNA repair mechanisms, telomere maintenance, and genomic stabilization.
Studies suggest these lasers can induce DNA repair pathways and influence telomere stability.

Conclusions:

Low power lasers show potential as therapeutic agents against DNA-harmful agents.
Modulation of DNA repair, telomere maintenance, and genomic stability are key mechanisms targeted by low power lasers.