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Historical perspectives on tardive dyskinesia
Stanley N Caroff1, Gabor S Ungvari2, David G Cunningham Owens3
1Corporal Michael J. Cresencz Veterans Affairs Medical Center and the Perelman School of Medicine at the University of Pennsylvania, University Avenue, Philadelphia, PA 19104, USA.
Journal of the Neurological Sciences
|February 19, 2018
Summary
Tardive dyskinesia (TD) is a movement disorder linked to antipsychotic drugs. Research is reviving interest in understanding and treating this iatrogenic condition, offering hope for patient recovery.
Area of Science:
- Neuroscience
- Pharmacology
- Movement Disorders
Background:
- Tardive dyskinesia (TD) is a hyperkinetic movement disorder.
- It is associated with dopamine receptor blocking agents, including antipsychotic medications.
Observation:
- Despite recognition 60 years ago, scientific and clinical interest in TD has fluctuated.
- Recent commercial interest has renewed focus on developing effective treatments for TD.
- Early research established TD as an iatrogenic disorder, but fundamental questions remain unresolved.
Findings:
- This review examines early clinical reports and controversies surrounding TD.
- It highlights advancements in understanding TD's clinical features and epidemiology.
- Unresolved questions from early investigations persist.
Implications:
- Continued research on TD as a serious adverse drug reaction can improve patient outcomes.
- Studying TD may offer insights into antipsychotic drug mechanisms.
- Research on TD can advance the understanding of psychomotor disorder pathophysiology and nosology.
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