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Update on visual function and choroidal-retinal thickness alterations in Parkinson's disease.
1Departamento de Oftalmología, Hospital Universitario Miguel Servet, Zaragoza, España.
Archivos De La Sociedad Espanola De Oftalmologia
|February 19, 2018
Summary
Optical coherence tomography (OCT) reveals retinal and choroidal changes in Parkinson's disease (PD). These OCT measurements may serve as a biomarker for PD progression and highlight early visual dysfunctions.
Area of Science:
- Ophthalmology
- Neurology
- Biomedical Imaging
Background:
- Parkinson's disease (PD) is a global neurodegenerative disorder affecting millions.
- Optical coherence tomography (OCT) studies since 2004 have indicated retinal layer alterations in PD patients.
- Discrepancies exist in OCT findings regarding PD, necessitating a comprehensive review.
Purpose of the Study:
- To review existing literature on OCT and PD.
- To identify specific retinal and choroidal parameters altered in PD.
- To assess the clinical utility of OCT biomarkers and understand the impact of visual dysfunctions in PD.
Main Methods:
- Systematic literature review of studies utilizing OCT in Parkinson's disease.
- Analysis of OCT parameters including retinal thickness and choroidal thickness.
- Correlation of OCT findings with PD severity, duration, and visual dysfunction.
Main Results:
- OCT measurements show potential as non-invasive biomarkers for PD progression.
- Some studies correlate retinal thickness with PD severity and duration.
- Recent Swept Source OCT studies report increased choroidal thickness in PD patients.
Conclusions:
- OCT is a valuable tool for detecting retinal and choroidal changes in Parkinson's disease.
- Altered retinal and choroidal parameters identified via OCT may offer clinical utility for PD management.
- Understanding visual dysfunctions associated with these changes is crucial for patient care.