Related Experiment Video
Updated: Feb 14, 2026
07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
1.2K
Reactive arthritis: update 2018.
A García-Kutzbach1, J Chacón-Súchite2, H García-Ferrer2
1AGAR, FM - UFM. Asociación Guatemalteca Anti-enfermedades Reumáticas, Facultad de Medicina, Universidad Francisco Marroquín, Guatemala City, CA, Guatemala. abraham@garciakutzbach.org.
Clinical Rheumatology
|February 19, 2018
Summary
Reactive arthritis (ReA) is an infection-induced systemic illness within the spondyloarthritis spectrum. It presents as sterile synovitis in genetically susceptible individuals, often with extra-articular symptoms.
Area of Science:
- Rheumatology
- Immunology
- Infectious Diseases
Background:
- Reactive arthritis (ReA) is now classified within the spondyloarthritis spectrum.
- Previously known as Reiter's syndrome, ReA is an infection-induced systemic condition.
- Characterized by sterile synovitis in genetically predisposed individuals.
Purpose of the Study:
- To define reactive arthritis within the broader context of spondyloarthritis.
- To highlight the infectious etiology and systemic nature of ReA.
- To describe the key clinical features, including synovitis and extra-articular manifestations.
Main Methods:
- Literature review and synthesis of current understanding of reactive arthritis.
- Classification of ReA within the spondyloarthritis disease group.
- Identification of characteristic clinical presentations and triggers.
Main Results:
- Reactive arthritis is an infection-induced systemic illness.
- It occurs in genetically susceptible individuals.
- Characterized by sterile joint inflammation (synovitis) and extra-articular symptoms secondary to distant infections.
Conclusions:
- Reactive arthritis is a distinct entity within the spondyloarthritis spectrum.
- Understanding its infectious origins and genetic predisposition is key.
- Management should consider both articular and extra-articular manifestations.
More Related Videos
Related Concept Videos
00:42Cross-reactivity
33.1K
Overview
33.1K
01:18Reactivity of Enols
4.2K
Enols are a class of compounds where a hydroxyl group is attached to a carbon–carbon double bond, which implies that it is a vinyl alcohol. A carbonyl compound with an α hydrogen undergoes keto–enol tautomerism and remains in equilibrium with its tautomer, the enol form. Usually, the keto tautomer is present in a higher concentration than the enol tautomer due to the higher bond energy of C=O compared to C=C. Moreover, the direction of the keto–enol equilibrium is...
4.2K
01:23Reactivity of Enolate Ions
3.4K
Enolate ions are formed by the acid–base reaction of a carbonyl compound with a base. This leads to deprotonation of the α hydrogen atom, leading to a resonance-stabilized enolate ion where one of the contributing structures is an oxyanion, which imparts additional stability. Therefore, the proton on the α carbon is more acidic in nature than that of other sp3-hybridized C–H bonds but less acidic than those in O–H bonds where the negative charge in the conjugate...
3.4K
01:11Radical Reactivity: Overview
2.8K
Radicals, the highly reactive species, gain stability by undergoing three different reactions. The first reaction involves a radical-radical coupling, in which a radical combines with another radical, forming a spin‐paired molecule. The second reaction is between a radical and a spin‐paired molecule, generating a new radical and a new spin‐paired molecule. The third reaction is radical decomposition in a unimolecular reaction, forming a new radical and a spin‐paired...
2.8K
01:16Radical Reactivity: Nucleophilic Radicals
2.7K
Radicals adjacent to electron-donating groups are called nucleophilic radicals. These radicals readily react with electrophilic alkenes. The SOMO–LUMO interactions are the driving force for the reaction, where the high-energy SOMO of the electron-rich, nucleophilic radicals interacts with the low-energy LUMO of the electron-deficient, electrophilic alkenes. Such SOMO–LUMO interactions are the basis of reactive radical traps, affecting the selectivity in radical reactions. For...
2.7K
01:33Radical Reactivity: Intramolecular vs Intermolecular
2.2K
Radical reactions can occur either intermolecularly or intramolecularly. In an intermolecular radical reaction, a nucleophilic radical adds to an electrophilic alkene or vice versa. In such reactions, the radical and generally the alkene, which is also called the radical trap, are two different molecules. Additionally, for such intermolecular reactions to occur, the radical trap must be active, present in an excess concentration, and the radical starting material must have a weak...
2.2K