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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

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Left ventricular structure and diastolic function by cardiac magnetic resonance imaging in hypertrophic

Binita Riya Chacko1, Gauri R Karur2, Kim A Connelly3

  • 1Department of Medical Imaging, St. Michael's Hospital, Toronto, Canada; Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India.

Indian Heart Journal
|February 20, 2018
PubMed

Insights

Maximum left ventricular wall thickness (MLVWT) correlates with diastolic function (TPF) in hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD). Late gadolinium enhancement (LGE) and right ventricular (RV) hypertrophy indicate worse diastolic dysfunction in HCM.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Cardiovascular Diseases

Background:

  • Diastolic dysfunction is prevalent in hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD).
  • The relationship between diastolic function and left ventricular (LV) parameters like maximum left ventricular wall thickness (MLVWT) and LV mass index (LVMI) requires further investigation.
  • Cardiac magnetic resonance imaging (CMR) offers advanced capabilities for assessing these relationships.

Purpose of the Study:

  • To evaluate the correlation between diastolic function measures and LV parameters (MLVWT, LVMI) in HCM, HHD, and controls using CMR.
  • To explore the association of LV parameters and diastolic function with late gadolinium enhancement (LGE) and right ventricular (RV) hypertrophy in HCM patients.

Main Methods:

  • A study cohort included 41 patients with HCM, 21 with HHD, and 20 controls.
  • CMR was utilized to measure peak filling rate (PFR), time to peak filling (TPF), MLVWT, and LVMI.
  • LGE and RV morphology were assessed in HCM patients.

Main Results:

  • MLVWT showed a significant correlation with TPF across all groups (HCM, HHD, controls).
  • LVMI did not correlate significantly with diastolic function (TPF).
  • In HCM, LGE extent correlated with MLVWT and TPF. RV hypertrophy was associated with increased MLVWT and TPF.

Conclusions:

  • MLVWT is a significant correlate of diastolic function (TPF) in HCM, HHD, and controls.
  • Diastolic dysfunction in HCM is not solely attributable to wall thickening; LGE and RV involvement suggest more severe myocardial disarray and fibrosis contributing to diastolic dysfunction.
Abstract

Keywords:
Diastolic functionHypertensionHypertrophic cardiomyopathyLeft ventricleMagnetic resonance imaging

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