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Moschamine-Related Indole Alkaloids.

Chengfeng Xia1, Xiaogang Tong1

  • 1Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan University, Kunming, China.

The Alkaloids. Chemistry and Biology
|February 20, 2018
PubMed
Summary

This review covers moschamine-related alkaloids, focusing on their isolation, structural characterization, and synthesis. It also details their antioxidant and other biological activities.

Keywords:
Chemical synthesisIndole alkaloidIsolationMoschamine

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Area of Science:

  • Natural Product Chemistry
  • Organic Synthesis
  • Pharmacology

Background:

  • Moschamine-related alkaloids are derived from feruloylserotonin through cyclization or dimerization.
  • These compounds are of interest due to their biological activities, particularly antioxidant properties.

Purpose of the Study:

  • To provide a comprehensive overview of moschamine-related alkaloids.
  • To detail their isolation, structural characterization, spectral data, and biological properties.
  • To summarize synthetic methodologies for their preparation.

Main Methods:

  • Literature review of isolation and structural elucidation studies.
  • Compilation of spectral data for characterization.
  • Analysis of reported synthetic routes and strategies.
  • Review of screened biological activities.

Main Results:

  • Detailed structural characterization and spectral data for isolated moschamine-related alkaloids are presented.
  • A range of biological properties, including antioxidant activities, are outlined.
  • Various synthetic protocols for generating these alkaloids are discussed, organized by key structural element formation.

Conclusions:

  • Moschamine-related alkaloids are a significant class of natural products with diverse biological activities.
  • Advances in isolation, characterization, and synthesis have expanded our understanding and accessibility of these compounds.