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The InR/Akt/TORC1 Growth-Promoting Signaling Negatively Regulates JAK/STAT Activity and Migratory Cell Fate during

Di Kang1, Dou Wang1, Jianbing Xu1

  • 1State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, 12 Xue-fu Road, Nanjing 210061, China.

Developmental Cell
|February 20, 2018
PubMed

Insights

The InR/Akt/TOR pathway suppresses border cell differentiation during Drosophila oogenesis by downregulating JAK/STAT signaling. This pathway coordinates cell growth and differentiation by stabilizing SOCS36E, a JAK/STAT inhibitor.

Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Molecular Biology

Background:

  • Cell growth and differentiation are fundamental developmental processes.
  • Coordination between cell growth and differentiation is crucial but poorly understood.
  • The JAK/STAT pathway is essential for border cell fate determination in Drosophila oogenesis.

Purpose of the Study:

  • To investigate the coordination between cell growth and cell differentiation.
  • To elucidate the role of the InR/Akt/TOR pathway in suppressing border cell fate.
  • To understand how cell growth pathways regulate developmental decisions.

Main Methods:

  • Investigated the InR/Akt/TOR pathway in Drosophila oogenesis.
  • Analyzed the interaction between TORC1, Raptor, and the JAK/STAT pathway.
  • Examined the effect of TORC1 on the protein stability of SOCS36E.

Main Results:

  • The growth-promoting InR/Akt/TOR pathway suppresses border cell differentiation.
  • InR/Akt/TOR signaling downregulates the JAK/STAT pathway via TORC1 and Raptor.
  • TORC1 enhances SOCS36E protein stability, a negative regulator of JAK/STAT signaling.

Conclusions:

  • TORC1 acts as a key regulator coordinating cell growth and differentiation.
  • The study reveals a novel mechanism linking growth pathways to developmental fate.
  • Findings provide insights into how cell growth influences cell fate decisions.
Keywords:
SOCS36ESTATTORC1cell growthcell migrationfate determination

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