Immune-mediated Neuropathies Our Experience over 3 Years

Area of Science:

• Neurology
• Immunology

Background:

• Immune-mediated neuropathies involve immune system dysregulation affecting peripheral nerves.
• These conditions represent a spectrum of disorders with varying clinical presentations.
• Early diagnosis and treatment are key to managing these treatable conditions.

Purpose of the Study:

• To analyze clinical, laboratory, and outcome parameters in patients with immune-mediated neuropathy.
• To evaluate the spectrum, subtypes, and treatment responses in a cohort of patients.

Main Methods:

• Retrospective analysis of consecutive patients diagnosed with immune-mediated neuropathy.
• Assessment of etiology, pathology, treatment, and patient outcomes.

Main Results:

• Sixty patients were identified: 31 acute and 29 chronic neuropathies.
• Common subtypes included motor dominant, MADSAM, and Miller Fisher.
• Nonsystemic vasculitis was observed in 16 chronic cases; HIV, POEMS, and diabetes mellitus were rare causes.

Conclusions:

• Immune-mediated neuropathies exhibit a wide clinical spectrum and variable treatment responses.
• The study observed nil mortality and minimal morbidity in the analyzed group.
• Prompt diagnosis is essential for favorable outcomes in immune-mediated neuropathies.