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Related Experiment Videos

Hansen's Neuritis Revisited - A Clinicopathological Study.

Navya Jaiswal1, Shrijeet Chakraborti1, Kashinath Nayak2

  • 1Department of Pathology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.

Journal of Neurosciences in Rural Practice
|February 20, 2018
PubMed
Summary

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This summary is machine-generated.

Hansen's neuritis (HN) is a challenging diagnosis, often affecting nerves with or without skin lesions. This study highlights its clinicopathological features, emphasizing the need for comprehensive diagnostic approaches including histopathology and bacillary detection.

Area of Science:

  • Neurology
  • Dermatology
  • Pathology

Background:

  • Leprosy can affect nerves exclusively or alongside skin manifestations, presenting diagnostic difficulties.
  • Hansen's neuritis (HN) contributes significantly to patient morbidity.
  • Understanding the clinicopathological spectrum of HN is crucial for effective management.

Purpose of the Study:

  • To elucidate the clinicopathological characteristics of Hansen's neuritis.
  • To analyze diagnostic challenges and outcomes associated with HN.
  • To provide insights into the histological subtypes and bacillary presence in HN cases.

Main Methods:

  • A retrospective review of histologically diagnosed HN cases from January 2010 to July 2017.
  • Analysis of clinical presentations, treatment histories, and patient outcomes.
Keywords:
Hansen's neuritislepra bacillimononeuritis multiplexpure neuritic leprosy

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  • Histopathological examination including Fite-Faraco staining for lepra bacilli.

    • Main Results:

    • 18 HN cases represented 3.97% of nerve biopsies; pure neuritic leprosy was most common (61.1%).
    • Mononeuritis multiplex was frequently observed in nerve conduction studies.
    • Histological findings varied, with borderline tuberculoid leprosy being the most prevalent subtype; lepra bacilli were detected in 44.4% of cases.

    Conclusions:

    • Accurate diagnosis of HN requires a thorough clinical evaluation, including skin assessment and neurological examination.
    • Histopathological examination and demonstration of lepra bacilli are essential for confirming HN.
    • Early and accurate diagnosis facilitates appropriate treatment and management of leprosy-induced nerve damage.