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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
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Related Experiment Video

Updated: Feb 14, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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Infectious mononucleosis and hepatic function.

Li Zhang1, Pingping Zhou2, Zhaowei Meng2

  • 1Department of Infectious Diseases, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.

Experimental and Therapeutic Medicine
|February 20, 2018
PubMed
Summary
This summary is machine-generated.

High transferase levels (ALT, AST, GGT) and low total bilirubin (TB) are associated with infectious mononucleosis (IM). These liver function test abnormalities, particularly elevated transferases in males and low bilirubin in females, can help predict IM risk.

Keywords:
Epstein-Barr virusbilirubininfectious mononucleosistransferase

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Clinical Biochemistry

Background:

  • Abnormal liver function is common in infectious mononucleosis (IM).
  • The reasons for elevated transferase levels over bilirubin abnormalities in IM remain unclear.
  • Investigating these associations in the Chinese population is crucial.

Purpose of the Study:

  • To investigate the association between liver function tests and infectious mononucleosis in the Chinese population.
  • To determine if elevated transferase levels or decreased bilirubin levels are predictive of IM.
  • To explore sex-specific differences in these associations.

Main Methods:

  • Enrolled 95 IM patients and 95 healthy controls, stratified by sex.
  • Utilized Receiver Operating Characteristic (ROC) curves to establish diagnostic cut-off values.
  • Employed binary logistic regression to analyze odds ratios (OR) for IM risk.

Main Results:

  • Significantly higher alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transferase (GGT) in IM patients compared to controls.
  • Significantly lower total bilirubin (TB) levels observed in IM patients.
  • Elevated transferases and low TB were predictive of IM, with increased risk particularly noted in males for high transferases and in females for low TB.

Conclusions:

  • High transferase levels (ALT, AST, GGT) are positively associated with IM, suggesting their utility in diagnosis, especially in males.
  • Low total bilirubin (TB) levels are negatively associated with IM, indicating potential as a predictive marker, particularly in females.
  • The study highlights distinct patterns of liver enzyme abnormalities in IM based on sex.