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Crizotinib-associated toxic epidermal necrolysis in an ALK-positive advanced NSCLC patient

Shaoyu Yang1, Liming Wu2, Xin Li1

  • 1Department of Medical Oncology, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, Zhejiang 310006, P.R. China.

Molecular and Clinical Oncology
|February 20, 2018
PubMed

Insights

Crizotinib, used for advanced non-small-cell lung cancer (NSCLC), can cause toxic epidermal necrolysis (TEN). This rare but severe skin reaction led to a patient

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Crizotinib is a targeted therapy for anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancer (NSCLC).
  • Toxic epidermal necrolysis (TEN) is a rare but severe adverse drug reaction.
  • Crizotinib has been associated with TEN as a potential side effect.

Purpose of the Study:

  • To report a fatal case of TEN in a patient treated with crizotinib for advanced NSCLC.
  • To increase awareness among clinicians regarding the risk of TEN during crizotinib therapy.

Main Methods:

  • Case report of a 75-year-old Chinese male patient.
  • Detailed clinical observation of adverse event development.
  • Review of crizotinib treatment and patient outcome.

Main Results:

  • The patient developed TEN after 56 days of crizotinib treatment.
  • The severe cutaneous adverse event predominantly involved skin and mucous membranes.
  • The patient ultimately demised due to the TEN.

Conclusions:

  • Clinicians should be vigilant for signs of TEN in patients receiving crizotinib.
  • Prompt recognition and management of TEN are crucial to improve patient outcomes.
  • This case highlights the potentially fatal nature of crizotinib-induced TEN.
Keywords:
crizotinibepidermalnecrolysisnon-small-cell lung cancertoxic

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