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Abdominal obesity adversely affects bone mass in children
Sowmya Krishnan1, Michael P Anderson2, David A Fields1
1Department of Pediatrics, University of Oklahoma Health Sciences Center, Harold Hamm Diabetes Center, Oklahoma City, OK 73104, United States.
World Journal of Clinical Pediatrics
|February 20, 2018
Summary
Childhood obesity, specifically abdominal fat, negatively impacts bone health in adolescents. However, this effect on bone mineral content is not linked to insulin resistance.
Area of Science:
- Pediatric Endocrinology
- Bone Metabolism
- Obesity Research
Background:
- Childhood obesity is a growing concern with potential long-term health implications.
- Insulin resistance is a metabolic abnormality often associated with obesity.
- The relationship between obesity, insulin resistance, and bone health in adolescents requires further investigation.
Purpose of the Study:
- To investigate the impact of childhood obesity and insulin resistance on bone health in pubertal adolescents and young adults.
- To determine if insulin resistance mediates the effect of obesity on bone parameters.
Main Methods:
- Cross-sectional study of 13-20 year olds, categorized as overweight/obese or normal weight.
- Assessment of pubertal stage (Tanner 3+), fasting blood work (glucose, insulin, CRP, lipids), and calculation of Homeostatic Model of Insulin Resistance (HOMA-IR).
- Measurement of body composition and bone mineral density using dual-energy X-ray absorptiometry (DXA).
Main Results:
- A significant inverse association was found between percent trunk fat and whole body bone mineral content (BMC).
- Homeostatic Model of Insulin Resistance (HOMA-IR) showed a positive association with whole body BMC.
- The adverse effect of abdominal adiposity on bone parameters was not mediated by insulin resistance.
Conclusions:
- Abdominal adiposity in adolescents may negatively affect overall bone parameters.
- Insulin resistance does not appear to be the mediating factor in the relationship between abdominal obesity and bone health in this population.
- Further research is warranted to understand the mechanisms linking abdominal fat to bone health in youth.
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