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Detection of Epstein-Barr and Human Papilloma Viruses in the Middle Ear Squamous Cell Carcinoma

Agus Surono1, Bambang Hariwiyanto1, Edhie Samodra1

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Gadjah Mada, Jl. Farmako, Sekip, Yogyakarta, Indonesia.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|February 20, 2018
PubMed

Insights

Epstein-Barr virus (EBV) and Human Papillomavirus (HPV) were detected in Indonesian middle ear squamous cell carcinoma (MESCC) tissues. These findings suggest viral infections may contribute to the development of this uncommon ear tumor.

Area of Science:

  • Otolaryngology
  • Oncology
  • Virology

Background:

  • Middle ear squamous cell carcinoma (MESCC) is an uncommon tumor often linked to chronic otitis media.
  • The exact causes of MESCC are multifactorial and not fully understood.
  • Epstein-Barr virus (EBV) and Human Papillomavirus (HPV) are suspected etiological factors in MESCC.

Purpose of the Study:

  • To investigate the presence of EBV and HPV in Indonesian MESCC cases.
  • To explore the potential role of these viruses in the pathogenesis of middle ear cancer.

Main Methods:

  • Analysis of seven paraffin-embedded MESCC biopsy tissues.
  • Immunohistochemistry staining using polyclonal antibodies against EBNA1 (for EBV) and HPV.
  • Detection of viral presence in tumor samples.

Main Results:

  • EBV was identified in 43% (3/7) of the samples.
  • HPV was detected in 29% (2/7) of the samples.
  • Co-infection with both EBV and HPV was observed in 14% (1/7) of the samples.

Conclusions:

  • The detection of EBV and HPV in Indonesian MESCC samples supports their potential role in the cancer's development.
  • Viral infections may be significant etiological factors in middle ear carcinogenesis.
  • Further research is warranted to elucidate the specific mechanisms of viral involvement.
Keywords:
EBVHPVImmunohistochemistryMiddle ear squamous cell carcinoma

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