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LPA Gene Polymorphisms and Gene Expression Associated with Coronary Artery Disease

Zi-Kai Song1, Hong-Yan Cao1, Hai-Di Wu1

  • 1Department of Cardiology, The First Hospital of Jilin University, Changchun, China.

Biomed Research International
|February 20, 2018
PubMed

Insights

The LPA gene rs6415085 polymorphism is linked to coronary artery disease (CAD) risk and higher lipoprotein(a) [Lp(a)] levels in the Chinese Han population. Increased LPA gene expression may contribute to CAD development.

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Molecular Biology

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • Lipoprotein(a) [Lp(a)] is an established risk factor for CAD, but the underlying genetic mechanisms require further elucidation.
  • The LPA gene plays a critical role in Lp(a) synthesis and assembly.

Purpose of the Study:

  • To investigate the association between LPA gene polymorphisms and CAD risk in the Chinese Han population.
  • To examine the relationship between LPA gene polymorphisms and plasma Lp(a) levels.
  • To analyze the effect of LPA gene expression on CAD risk and Lp(a) levels.

Main Methods:

  • A case-control study was conducted involving 92 CAD cases and 32 controls from the Chinese Han population.
  • Five single nucleotide polymorphisms (SNPs) in the LPA gene (rs1367211, rs3127596, rs6415085, rs9347438, and rs9364559) were genotyped using the SEQUENOM Mass-ARRAY system.
  • Quantitative real-time PCR was employed to measure LPA gene mRNA expression levels in blood samples.

Main Results:

  • The T allele of rs6415085 was significantly more frequent in the CAD case group compared to the control group (P < 0.05).
  • Individuals with the TT/TG genotype at rs6415085 exhibited significantly higher plasma Lp(a) levels than those with the GG genotype (P < 0.05).
  • LPA gene mRNA expression levels were significantly elevated in the CAD case group compared to the control group (P < 0.05).

Conclusions:

  • The LPA gene rs6415085 polymorphism is associated with an increased risk of CAD and elevated plasma Lp(a) levels in the Chinese Han population.
  • Increased LPA gene mRNA expression may represent a key mechanism contributing to the development of CAD.
  • These findings highlight the role of LPA gene variants and expression in CAD pathogenesis and suggest potential therapeutic targets.

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