Related Experiment Video For Crohn disease
Updated: Feb 14, 2026

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
Published on: April 18, 2025
Signet Ring Cell Carcinoma, Ileal Crohn Disease or Both? - A Case of Diagnostic Challenge
Joana R Carvalho1, Joana Tavares2, Inês Goulart1
1Department of Gastroenterology, CHLN - Hospital de Santa Maria, Lisbon, Portugal.
Abstract:
Signet ring cell carcinoma is a rare form of adenocarcinoma that predominantly affects the stomach. Signet ring cell carcinoma originated from the ileum is extremely rare and the prognosis is poor. We present a case of small bowel obstruction with features suggesting Crohn disease of the ileum. The symptoms were chronic diarrhea and abdominal pain with a family history of inflammatory bowel disease. The patient underwent surgery and histopathology revealed both aspects of signet ring cell carcinoma and Crohn disease of the ileum. An association between long-standing inflammation and the development of this subtype of tumor has been proposed but there are no established surveillance guidelines for small bowel neoplasm in inflammatory bowel disease.
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