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Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

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Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
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Bipolar Junction Transistors (BJTs) are essential elements in electronic circuits, playing a crucial role in the functionality of amplifiers, memories, and microprocessors. These transistors can be designed as NPN or PNP based on their doping patterns. They consist of three layers: the emitter, base, and collector. The configuration of these layers and their respective doping levels—with N-type or P-type impurities—define the transistor's type and its operational...
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Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Modeling suicide in bipolar disorders.

Gin S Malhi1,2,3, Tim Outhred1,2,3, Pritha Das1,2,3

  • 1Academic Department of Psychiatry, Northern Sydney Local Health District, St Leonards, NSW, Australia.

Bipolar Disorders
|February 20, 2018
PubMed
Summary
This summary is machine-generated.

Suicide is highly prevalent in bipolar disorder, necessitating improved prediction and prevention strategies. This review introduces a novel integrated model to understand the suicide process in bipolar disorder, from ideation to action.

Keywords:
bipolar disordermood disordersneurocognitive modelssuicidesuicide modelssuicide process

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Public Health

Background:

  • Suicide is a significant concern in bipolar disorder, occurring 20-30 times more frequently than in the general population.
  • Understanding the complex factors contributing to suicide in bipolar disorder is crucial for effective prevention and intervention.
  • Existing models offer insights but a comprehensive, integrated approach is needed.

Purpose of the Study:

  • To propose a novel integrated model for understanding the suicide process in bipolar disorder.
  • To synthesize current knowledge and recent evidence on suicide risk and mechanisms in bipolar disorder.
  • To identify potential therapeutic targets for suicide prevention in bipolar disorder.

Main Methods:

  • A comprehensive literature search was conducted in Scopus, PubMed, and PsycINFO.
  • Keywords included "suicide", "suicide in bipolar disorders", "suicide process", "suicide risk", "neurobiology of suicide", and "suicide models".
  • Bibliographies of relevant articles were reviewed for additional pertinent sources.

Main Results:

  • Suicide risk in bipolar disorder is influenced by epigenetic mechanisms, neurobiological factors, neurocognitive functioning, and social environment.
  • Several theoretical models (diathesis-stress, ideation-to-action, interpersonal theory, motivational-volitional, three-step theory) inform the understanding of the suicide process.
  • These models provide a foundation for an integrated model illuminating the progression from suicidal ideation to action.

Conclusions:

  • A multidimensional and integrated approach is essential to reduce suicide rates in bipolar disorder.
  • The proposed integrated model identifies measurable components of the suicide process.
  • This model offers potential for novel therapeutic targets and has implications for clinical practice and research.