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Male infertility is associated with altered treatment course of men with cancer

O Eminaga1,2, S Li3, L C Baker4

  • 1Department of Urology, Stanford University School of Medicine, Stanford, CA, USA.

Andrology
|February 20, 2018
PubMed

Insights

Infertile men with cancer receive different cancer treatments. They experience shorter radiation therapy and less combined radiation/chemotherapy compared to fertile or vasectomized men.

Area of Science:

  • Oncology
  • Reproductive Medicine
  • Health Services Research

Background:

  • Infertility is a growing concern for men diagnosed with cancer.
  • Cancer treatments can impact male fertility, necessitating studies on cancer management in infertile populations.
  • Understanding treatment variations is crucial for optimizing care for infertile men with cancer.

Purpose of the Study:

  • To compare cancer treatment patterns in infertile men versus men who underwent vasectomy and age-matched controls.
  • To identify differences in chemotherapy, radiation, and surgical treatment modalities.
  • To investigate variations in multimodal treatment approaches for specific cancer types.

Main Methods:

  • Retrospective analysis of the Truven Health MarketScan Claims database (2001-2009).
  • Identification of infertile men using diagnosis and treatment codes.
  • Comparison with vasectomized men and a non-infertile, non-vasectomized control group.
  • Analysis of cancer types diagnosed after infertility diagnosis, focusing on chemotherapy (CTX), radiation therapy (RTX), and surgical treatment (ST).

Main Results:

  • Chemotherapy (CTX) distribution was similar across infertile, vasectomized, and control groups.
  • Radiation therapy (RTX) duration was shorter in infertile men.
  • Multimodal treatment (RTX and CTX) was half as frequent in infertile men.
  • For non-Hodgkin lymphoma (NHL), infertile men had shorter RTX and CTX durations compared to controls.

Conclusions:

  • Infertile men diagnosed with cancer, particularly NHL, exhibit distinct treatment patterns.
  • Shorter radiation therapy and reduced use of combined radiation/chemotherapy are observed in infertile men.
  • These treatment differences may stem from variations in disease stage, tumor biology, or treatment response in infertile populations.
Keywords:
NHLcancerinfertilitymale infertilitynon-Hodgkin lymphomatreatment coursevasectomy

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