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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
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Atopy Associated With Positive Patch Test and Possible Allergic Contact Dermatitis
Mark G Kirchhof1, Gillian C de Gannes2,3
11 Division of Dermatology, Department of Medicine, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada.
Journal of Cutaneous Medicine and Surgery
|February 20, 2018
Summary
Individuals with a personal or family history of atopy have a higher risk of developing allergic contact dermatitis (ACD). This suggests proactive allergen avoidance and emollient use for children of atopic parents.
Area of Science:
- Dermatology
- Allergology
- Immunology
Background:
- Atopy is a genetic predisposition to allergic reactions and elevated immunoglobulin E (IgE).
- Clinical manifestations include asthma, atopic dermatitis (AD), and allergic rhinoconjunctivitis (ARC).
Purpose of the Study:
- To investigate if cutaneous delayed hypersensitivity reactions (CDHRs) via patch testing are more prevalent in patients with atopy.
- To assess the impact of personal and familial history of atopy on CDHRs.
Main Methods:
- Retrospective analysis of 1515 patients from the UBC Contact Dermatitis Clinic patch test database (4-year period).
- Recorded personal history of asthma, AD, and ARC.
- Obtained family history of atopy and its manifestations.
Main Results:
- A personal history of atopy showed an odds ratio (OR) of 1.39 for a positive patch test.
- A family history of atopy had a higher OR of 1.69 for a positive patch test.
- Personal history of respiratory atopy did not significantly increase the probability of a positive patch test (OR = 1.03).
Conclusions:
- Patients with personal or family history of atopy face an increased risk of allergic contact dermatitis (ACD).
- Findings support a link between atopy and ACD.
- Recommends allergen avoidance and prophylactic emollient use for children of atopic parents.
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