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Related Concept Videos

Data Collection II01:29

Data Collection II

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The nursing history captures and records the patient's health status, so that a care plan evolves to meet the patient's individual needs. The nursing health history is a part of the initial assessment. A comprehensive history covers all health dimensions and plays a significant role in the assessment process. A comprehensive history includes the patient's biographical information, reasons for seeking health care, expectations, present and past health history, medications, and...
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Data Collection I01:30

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Data collection gathers information needed to make accurate judgments about a patient's present condition. During a health history interview, subjective data is collected from the patient, their caregivers, or family members, and objective data is collected through observations and physical assessment. Patients are the primary source of subjective data. Thus information gathered from patients through interviews, observations, and physical examination is primary data. Secondary sources of...
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Data Collection by Experiments01:13

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Data collection is a systematic method of obtaining, observing, measuring, and analyzing accurate information. An experimental study is a standard method of data collection that involves the manipulation of the samples by applying some form of treatment prior to data collection. It refers to manipulating one variable to determine its changes on another variable. The sample subjected to treatment is known as “experimental units.”
An example of the experimental method is a public...
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Data Collection by Survey01:07

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The systematic method of obtaining and analyzing accurate information of a population is called data collection. A survey is a standard method of data collection that involves collecting information from a target human population about their experience, opinion, or knowledge of a product, service, or process. The responses are recorded and interpreted. The most common survey examples are written questionnaires, face-to-face or telephonic conversations, focus groups, and electronic (e-mail or...
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Data Collection by Observations01:08

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Data collection refers to a systematic way of obtaining, observing, measuring, and analyzing accurate information. Observational studies are one of the most widely used methods of data collection. It involves collecting data by observing the behavior and physical characteristics of a sample without making any modifications to the sample.
An astronomer viewing the motion and brightness of stars in the sky and recording the data is an example of observational data collection. A botanist recording...
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Data Collection III01:05

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The physical assessment examines the patient for objective data that defines the patient's condition, and aids in formulating the nursing care plan. The purpose of physical assessment is a health status appraisal, which includes identifying health problems, and establishing a database for nursing intervention.
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Related Experiment Video

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Author Spotlight: High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography
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SCN5A: the greatest HITS collection.

David S Park, Glenn I Fishman

    The Journal of Clinical Investigation
    |February 20, 2018
    PubMed
    Summary

    A common genetic variant linked to heart failure (HF) mortality risk affects SCN5A gene expression via microRNA (miR) mechanisms. This finding suggests that reduced SCN5A may worsen HF progression and cardiac remodeling.

    Area of Science:

    • Cardiovascular Medicine
    • Genetics
    • Molecular Biology

    Background:

    • Heart failure (HF) is a major global health concern, often termed the cardiovascular epidemic.
    • Identifying molecular factors driving HF progression and mortality is crucial for developing effective treatments.

    Purpose of the Study:

    • To investigate the link between a specific common genetic variant and heart failure (HF) mortality risk.
    • To elucidate the molecular mechanisms, including microRNA (miR)-dependent pathways, regulating SCN5A expression in HF.
    • To examine the functional consequences of SCN5A haploinsufficiency on cardiac remodeling and reactive oxygen species (ROS) accumulation.

    Main Methods:

    • Analysis of a common genetic variant associated with HF mortality risk.
    • Investigation of microRNA-dependent regulation of SCN5A gene expression.

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  • Utilizing a genetically engineered murine model to study SCN5A haploinsufficiency.
  • Assessment of reactive oxygen species (ROS) levels and cardiac remodeling in the murine model.

    • Main Results:

    • A common variant was identified that regulates SCN5A expression through microRNA (miR)-dependent mechanisms, correlating with HF mortality risk.
    • SCN5A haploinsufficiency in a murine model led to increased accumulation of reactive oxygen species (ROS).
    • Data suggest that even a modest decrease in SCN5A expression can promote pathological cardiac remodeling and HF progression.

    Conclusions:

    • A novel link between a common genetic variant, miR-dependent SCN5A regulation, and HF mortality risk has been uncovered.
    • Reduced SCN5A expression, potentially due to genetic variants, may contribute to HF progression through mechanisms involving ROS and cardiac remodeling.
    • These findings highlight SCN5A as a potential therapeutic target for managing HF progression and improving patient outcomes.