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Related Concept Videos

Real Number Operations01:27

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The concept of real numbers includes all the values that can be represented on a continuous number line. The system began with basic counting values used for enumeration. It later expanded to include values that represent the absence of quantity and opposites of the counting values. When situations required expressing parts of a whole or dividing quantities evenly, values capable of representing such proportions were developed. When written using decimal notation, these values can end or repeat...
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Related Experiment Video

Updated: Feb 14, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
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B cells in operational tolerance.

M Chesneau1, R Danger1, J-P Soulillou2

  • 1Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; LabEx IGO "Immunotherapy, Graft, Oncology," Nantes, France.

Human Immunology
|February 20, 2018
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Summary

Patients developing operational tolerance after organ transplant show unique immune signatures. B cells may serve as biomarkers to guide safe reduction or withdrawal of immunosuppression, improving transplant outcomes.

Keywords:
B cellsBiomarkersOperational tolerance

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Area of Science:

  • Immunology
  • Transplantation Medicine
  • Biomarker Discovery

Background:

  • Organ transplantation is vital for end-stage organ failure but necessitates long-term immunosuppression with significant side effects.
  • Operational tolerance, characterized by graft survival without immunosuppression, occurs rarely in transplant recipients.
  • Understanding the mechanisms of operational tolerance is crucial for refining post-transplant management.

Purpose of the Study:

  • To review studies investigating the role of B cells in operational tolerance.
  • To explore the potential of B cells as biomarkers for predicting immunologic risk in transplant patients.
  • To discuss how B cell signatures can inform personalized immunosuppression strategies.

Main Methods:

  • Review of existing literature on operational tolerance in transplantation.
  • Analysis of genetic, phenotypic, and functional signatures in tolerant patients.
  • Focus on studies identifying B cell involvement and characteristics.

Main Results:

  • Patients with operational tolerance exhibit distinct immunological profiles.
  • B cells are implicated as potential biomarkers associated with operational tolerance.
  • These B cell signatures may predict immunologic risk and guide treatment adjustments.

Conclusions:

  • B cells show promise as biomarkers for operational tolerance in organ transplantation.
  • Identifying B cell profiles can aid in adapting immunosuppressive therapy.
  • Utilizing B cells as predictive tools may allow for safer reduction or withdrawal of immunosuppression.