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Updated: Jul 12, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

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Published on: August 2, 2016

Programmed drug delivery system based on optimized "size decrease and hydrophilicity/hydrophobicity transformation"

Yuanyuan Liu1, Lian Li1, Lijia Li1

  • 1Key Laboratory of Drug Targeting and Drug Delivery System (Ministry of Education), West China School of Pharmacy, Sichuan University, No. 17, Block 3, South Renmin Road, Chengdu 610041, P.R. China.

Nanomedicine : Nanotechnology, Biology, and Medicine
|February 20, 2018
PubMed
Summary

A novel drug delivery system, gelatin nanoparticle-doxorubicin-lactose (GNPs-Dox-Lac), overcomes barriers for enhanced hepatocellular carcinoma (HCC) therapy. This system achieved a 90.8% tumor inhibition rate with minimal toxicity in vivo.

Keywords:
Drug delivery systemEnvironment-responsiveHepatocellular carcinoma therapyHydrophilicity/hydrophobicity transformationSize decrease

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