Related Experiment Video
Updated: Feb 14, 2026

An Epithelial Abrasion Model for Studying Corneal Wound Healing
Published on: December 29, 2021
Neuregulin-1 accelerates corneal epithelial wound healing
Won-Yong Jeong1, Hye-Young Yoo1, Chan-Wha Kim1
1a Department of Biotechnology, BK21 Plus Program, College of Life Sciences and Biotechnology , Korea University , Seoul , Korea.
Abstract:
Corneal epithelial cells (CECs) play an important role in the function of the cornea, and are maintained by corneal epithelial stem cells (CESCs). Recent studies have shown that neuronal growth factors affect the proliferation and migration of CESCs. Neuregulin-1 (NR-1) is a neuronal growth factor that is expressed in the early stages of brain development. The aim of this study was to determine whether NR-1 activates corneal wound healing. We observed that NR-1 activated both proliferation and migration of CECs. In addition, the colony-forming efficacy of CESCs was enhanced. In mice, NR-1 treatment improved corneal wound healing. Furthermore, the expression of markers of corneal epithelium maintenance (ΔNp63) and CESC proliferation (Bmi-1 and Abcg2) was increased. These effects were mediated by intracellular signalling pathways (Stat3, Erk1/2 and p38). Taken together, our results suggest that NR-1 accelerates the recovery of corneal wounds, and may represent a novel treatment for corneal damage.
Related Concept Videos
Accelerators
The effectiveness of calcium chloride can...
Average Acceleration
Instantaneous Acceleration
Acceleration Vectors
Accelerating Fluids
The motion of the liquid within this infinitesimal cylinder is considered to obtain the pressure difference. Three vertical forces act on this liquid:
Accelerated Curing of Concrete

