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Predominance of community-associated sequence type 59 methicillin-resistant Staphylococcus aureus in a paediatric

Qifa Song1, Junhua Wu2, Peisen Ruan2

  • 1Department of Microbiology, Ningbo Municipal Centre for Disease Control and Prevention, Ningbo, Zhejiang Province, PR China.

Journal of Medical Microbiology
|February 21, 2018
PubMed
Abstract

Insights

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is prevalent in pediatric intensive care units (PICUs). ST59 CA-MRSA strains are indistinguishable from hospital-associated MRSA, highlighting the need for combined typing methods.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Genetics

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat in healthcare settings.
  • Distinguishing between community-associated (CA) and hospital-associated (HA) MRSA is crucial for infection control.
  • Paediatric intensive care units (PICUs) are vulnerable to MRSA colonization and infection.

Purpose of the Study:

  • To determine the molecular types of MRSA in a PICU.
  • To analyze the distribution of CA-MRSA and HA-MRSA isolates.
  • To assess the extent of CA-MRSA introduction into the PICU environment.

Main Methods:

  • MRSA surveillance was conducted in a PICU from 2013-2016.
  • Genetic diversity was assessed using pulsed-field gel electrophoresis (PFGE) and spa typing.
  • Antibiograms and virulence factor profiles were analyzed.

Main Results:

  • Sixty MRSA isolates were identified from 2684 specimens.
  • Forty-three isolates were identified as ST59 CA-MRSA, showing genetic and phenotypic diversity.
  • ST59 MRSA isolates were associated with both community and hospital acquisition, causing colonization and infections.

Conclusions:

  • A predominant ST59 CA-MRSA strain has significantly impacted the PICU.
  • ST59 CA-MRSA and HA-MRSA in the PICU have become indistinguishable.
  • Combined typing and epidemiological data are essential for differentiating outbreaks from endemic MRSA cases.
Keywords:
community-associated MRSAhospital-associated MRSAmethicillin-resistant Staphylococcus aureus (MRSA)paediatric intensive care unit (PICU)

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