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Amoxicillin-tolerant Pasteurella multocida strain isolated from chronic dermohypodermitis after suboptimal exposure

A Limelette1,2, D Giusti3, D Anuset4

  • 1Laboratoire de Bactériologie, Hôpital Robert Debré, Avenue Général Koenig, 51100 Reims, France.

Journal of Medical Microbiology
|February 21, 2018
PubMed

Insights

A rare Pasteurella multocida strain causing chronic infection showed amoxicillin tolerance, not increased resistance or slower growth. Tolerance alone may not explain chronic dermohypodermitis in immunocompetent individuals.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Dermatology

Background:

  • Pasteurella multocida is infrequently implicated in chronic human infections.
  • Chronic dermohypodermitis is a rare manifestation of Pasteurella multocida infection.

Purpose of the Study:

  • To investigate the characteristics of a P. multocida strain isolated from a chronic human infection.
  • To compare this strain with those from acute infections regarding antibiotic susceptibility, serum resistance, and immune cell activation.

Main Methods:

  • Isolation of P. multocida from a chronic skin infection biopsy.
  • Comparative analysis of growth rate, amoxicillin Minimal Inhibitory and Bactericidal Concentrations (MIC and MBC), serum resistance, and neutrophil granulocyte activation.
  • Evaluation of bacterial response to suboptimal amoxicillin exposure.

Main Results:

  • The chronic infection strain exhibited amoxicillin tolerance but not increased resistance.
  • No significant differences were observed in growth rate, serum resistance, or neutrophil activation compared to acute infection strains.
  • Suboptimal amoxicillin exposure did not alter the growth rate of the chronic strain.

Conclusions:

  • Amoxicillin tolerance in P. multocida may contribute to chronic infections but is likely insufficient alone in immunocompetent hosts.
  • Further research is needed to understand the pathogenesis of chronic P. multocida infections.
Keywords:
Pasteurella multocidaamoxicillingrowth ratehumantolerant

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