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Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Hypercoagulability and Vascular Disease.

Ali T Taher¹, Maria Domenica Cappellini², Rayan Bou-Fakhredin³

¹Department of Internal Medicine, Naef K. Basile Cancer Institute, American University of Beirut Medical Center, PO Box 11-0236, Beirut 11072020, Lebanon.

Hematology/Oncology Clinics of North America

|February 21, 2018

Summary

Thalassemia patients, especially those not requiring transfusions, have a higher risk of blood clots due to a hypercoagulable state. This review explores the causes, prevention, and management of thrombosis in thalassemia.

Keywords:

Cerebrovascular disease Hypercoagulable state Pulmonary hypertension Thrombosis

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Area of Science:

Hematology
Vascular Medicine
Genetics

Background:

Nontransfusion-dependent β-thalassemia syndromes are associated with a high incidence of thrombotic events.
This suggests an underlying hypercoagulable state in thalassemia patients.

Purpose of the Study:

To elucidate the mechanisms driving hypercoagulability in thalassemia.
To review clinical experience and evidence regarding the prevention and management of thrombosis in this population.

Main Methods:

Literature review of studies on thalassemia and thrombosis.
Analysis of mechanisms contributing to hypercoagulability.
Synthesis of clinical data on prevention and management strategies.

Main Results:

Identified key mechanisms contributing to hypercoagulability in thalassemia.
Summarized clinical observations and treatment outcomes.
Highlighted gaps in current knowledge and management guidelines.

Conclusions:

Hypercoagulability is a significant concern in nontransfusion-dependent β-thalassemia.
Further research is needed to optimize thrombotic event prevention and management strategies.