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Updated: Feb 14, 2026

Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution
Published on: September 21, 2012
Mucins: Structural diversity, biosynthesis, its role in pathogenesis and as possible therapeutic targets
Suresh Sulekha Dhanisha1, Chandrasekharan Guruvayoorappan1, Sudarsanan Drishya1
1Laboratory of Immunopharmacology and Experimental Therapeutics, Division of Cancer Research, Regional Cancer Centre, Medical College Campus, Thiruvananthapuram 695011, Kerala, India.
Abstract:
Mucins are the main structural components of mucus that create a selective protective barrier for epithelial surface and also execute wide range of other physiological functions. Mucins can be classified into two types, namely secreted mucins and membrane bounded mucins. Alterations in mucin expression or glycosylation and mislocalization have been seen in various types of pathological conditions such as cancers, inflammatory bowel disease and ocular disease, which highlight the importance of mucin in maintaining homeostasis. Hence mucins can be used as attractive target for therapeutic intervention. In this review, we discuss in detail about the structural diversity of mucins; their biosynthesis; its role in pathogenesis; regulation and as possible therapeutic targets.
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