Related Experiment Video
Updated: Feb 14, 2026
10:51
Preparation and Metabolic Assay of 3-dimensional Spheroid Co-cultures of Pancreatic Cancer Cells and Fibroblasts
Published on: August 23, 2017
12.9K
B-Cell Metabolic Remodeling and Cancer
Davide G Franchina1, Melanie Grusdat1, Dirk Brenner2
1Department of Infection and Immunity, Experimental and Molecular Immunology, Luxembourg Institute of Health, 29 rue Henri Koch, L-4354 Esch-sur-Alzette, Luxembourg.
Trends in Cancer
|February 21, 2018
Summary
B cells require precise metabolic control for immune responses and normal development. Dysregulated metabolism, influenced by factors like Myc and HIF-1α, can lead to B-cell cancers.
Area of Science:
- Immunology
- Cellular Metabolism
- Cancer Biology
Background:
- Immune cells, including B lymphocytes, exhibit diverse metabolic needs crucial for their functions.
- B cells must manage significant metabolic shifts during activation, proliferation, and antibody secretion.
- Imbalances in metabolic regulation are linked to B-cell malignancies.
Purpose of the Study:
- To provide a comprehensive overview of B-cell metabolism during normal development and oncogenesis.
- To highlight key metabolic regulators impacting B-cell fate.
- To emphasize the roles of myelocytomatosis virus oncogene cellular homolog (Myc) and hypoxia-inducible factor 1-α (HIF-1α).
Main Methods:
- Literature review and synthesis of current research on B-cell metabolism.
- Analysis of metabolic pathways in B cells during different functional states.
- Examination of regulatory mechanisms involving transcription factors like Myc and HIF-1α.
Main Results:
- B cells exhibit distinct metabolic profiles correlating with their activation status and functional demands.
- Key regulators such as Myc and HIF-1α significantly influence B-cell metabolism and fate.
- Metabolic dysregulation is a common feature in B-cell oncogenesis.
Conclusions:
- Understanding B-cell metabolic control is vital for comprehending humoral immunity and B-cell development.
- Targeting metabolic pathways may offer therapeutic strategies for B-cell malignancies.
- Further research is needed to fully elucidate the complex interplay between metabolism and B-cell fate.
Related Concept Videos
02:54Nucleosome Remodeling
11.3K
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
11.3K
00:52What is Metabolism?
132.6K
Overview
132.6K
01:40Bone Remodeling
40.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.5K
01:31Osteoclasts in Bone Remodeling
4.3K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.3K
01:35Cancer Cell Migration through Invadopodia
3.3K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.3K
02:53Adaptive Mechanisms in Cancer Cells
7.2K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.2K